Growth differentiation factor

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*'''GDF-8''' or '''myostatin''', controls the growth of muscle tissue<ref>PMID:10610713</ref>. For more details see [[Group:MUZIC:Myostatin]].<br />
*'''GDF-8''' or '''myostatin''', controls the growth of muscle tissue<ref>PMID:10610713</ref>. For more details see [[Group:MUZIC:Myostatin]].<br />
*'''GDF-11''' or '''bone morphogenetic protein 11''' is a circulating factor that reverses age-related cardiac hypertrophy<ref>PMID:23663781</ref>.
*'''GDF-11''' or '''bone morphogenetic protein 11''' is a circulating factor that reverses age-related cardiac hypertrophy<ref>PMID:23663781</ref>.
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</StructureSection>
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*'''GDF-15''' or '''placental bone morphogenetic protein''' protects the hart from ischmia and reperfusion injury<ref>PMID:16484622</ref>.
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See also [[Growth factors]] and [[Bone morphogenetic protein]].
==3D structures of growth differentiation factor==
==3D structures of growth differentiation factor==
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[[Growth differentiation factor 3D STRUCTURES]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*GDF-2
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**[[1zkz]], [[4mpl]] – hGDF residues 320-493 – human <br />
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**[[4fao]] – hGDF residues 320-493 + serine/threonine-protein kinase receptor + activin receptor<br />
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**[[4ycg]], [[4yci]] – mGDF residues 23-318 + hGDF residues 320-493 - mouse<br />
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*GDF-5
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**[[2bhk]], [[1waq]] – hGDF <br />
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**[[3evs]] – hGDF + bone morphogenetic receptor <br />
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**[[3qb4]] – hGDF (mutant) + bone morphogenetic receptor <br />
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**[[5hk5]] – hGDF + gremlin-2 <br />
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*GDF-8
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**[[5ji1]] – mGDF – mouse <br />
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**[[3hh2]] – mGDF + follistatin <br />
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**[[3sek]] – mGDF + follistatin-related protein <br />
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**[[5f3hf]], [[5f3b]] – hGDF + antibody <br />
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*GDF-11
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**[[5uhm]], [[5e4g]] – hGDF <br />
 
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**[[5jhw]] – hGDF + follistatin <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of growth differentiation factor GDF-5 (green and aqua) complex with bone morphogenetic receptor (pink and olive) (PDB entry 3evs)

Drag the structure with the mouse to rotate

References

  1. ↑ Jin L, Li X. Growth differentiation factor 5 regulation in bone regeneration. Curr Pharm Des. 2013;19(19):3364-73. PMID:23432680
  2. ↑ Ferrell RE, Conte V, Lawrence EC, Roth SM, Hagberg JM, Hurley BF. Frequent sequence variation in the human myostatin (GDF8) gene as a marker for analysis of muscle-related phenotypes. Genomics. 1999 Dec 1;62(2):203-7. PMID:10610713 doi:http://dx.doi.org/10.1006/geno.1999.5984
  3. ↑ Loffredo FS, Steinhauser ML, Jay SM, Gannon J, Pancoast JR, Yalamanchi P, Sinha M, Dall'Osso C, Khong D, Shadrach JL, Miller CM, Singer BS, Stewart A, Psychogios N, Gerszten RE, Hartigan AJ, Kim MJ, Serwold T, Wagers AJ, Lee RT. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell. 2013 May 9;153(4):828-39. doi: 10.1016/j.cell.2013.04.015. PMID:23663781 doi:http://dx.doi.org/10.1016/j.cell.2013.04.015
  4. ↑ Ago T, Sadoshima J. GDF15, a cardioprotective TGF-beta superfamily protein. Circ Res. 2006 Feb 17;98(3):294-7. doi: 10.1161/01.RES.0000207919.83894.9d. PMID:16484622 doi:http://dx.doi.org/10.1161/01.RES.0000207919.83894.9d

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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