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1iv3
From Proteopedia
(Difference between revisions)
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<StructureSection load='1iv3' size='340' side='right'caption='[[1iv3]], [[Resolution|resolution]] 1.52Å' scene=''> | <StructureSection load='1iv3' size='340' side='right'caption='[[1iv3]], [[Resolution|resolution]] 1.52Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1iv3]] is a 6 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1iv3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IV3 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1iv1|1iv1]], [[1iv2|1iv2]], [[1iv4|1iv4]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1iv1|1iv1]], [[1iv2|1iv2]], [[1iv4|1iv4]]</div></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.12 4.6.1.12] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iv3 OCA], [https://pdbe.org/1iv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iv3 RCSB], [https://www.ebi.ac.uk/pdbsum/1iv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iv3 ProSAT], [https://www.topsan.org/Proteins/RSGI/1iv3 TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ISPF_THET8 ISPF_THET8]] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).<ref>PMID:12499535</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 11:06, 4 August 2021
Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase (bound form MG atoms)
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Categories: Flavobacterium thermophilum yoshida and oshima 1971 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | Large Structures | Kishida, H | Kuzuyama, T | Park, S Y | Structural genomic | Sirouzu, M | Tame, J R.H | Terada, T | Unzai, S | Wada, T | Yokoyama, S | Isoprenoid | Lyase | Non-mevalonate | Rsgi | Synthase

