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2psm
From Proteopedia
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==Crystal structure of Interleukin 15 in complex with Interleukin 15 receptor alpha== | ==Crystal structure of Interleukin 15 in complex with Interleukin 15 receptor alpha== | ||
| - | <StructureSection load='2psm' size='340' side='right' caption='[[2psm]], [[Resolution|resolution]] 2.19Å' scene=''> | + | <StructureSection load='2psm' size='340' side='right'caption='[[2psm]], [[Resolution|resolution]] 2.19Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2psm]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2psm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PSM FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand= | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Il15 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Il15 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Il15ra ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2psm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2psm OCA], [https://pdbe.org/2psm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2psm RCSB], [https://www.ebi.ac.uk/pdbsum/2psm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2psm ProSAT], [https://www.topsan.org/Proteins/RSGI/2psm TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/IL15_MOUSE IL15_MOUSE]] Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha. [[https://www.uniprot.org/uniprot/I15RA_MOUSE I15RA_MOUSE]] High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Signal transduction seems to involve STAT3, STAT5, STAT6, JAK2 and SYK. Expression of different isoforms may alter or interfere with signal transduction.<ref>PMID:12734349</ref> <ref>PMID:17947230</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ps/2psm_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ps/2psm_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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==See Also== | ==See Also== | ||
| - | *[[Interleukin|Interleukin]] | + | *[[Interleukin 3D structures|Interleukin 3D structures]] |
| - | *[[Interleukin receptor|Interleukin receptor]] | + | *[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Lk3 transgenic mice]] | [[Category: Lk3 transgenic mice]] | ||
[[Category: Kanagawa, O]] | [[Category: Kanagawa, O]] | ||
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[[Category: Terada, T]] | [[Category: Terada, T]] | ||
[[Category: Yokoyama, S]] | [[Category: Yokoyama, S]] | ||
| + | [[Category: Alternative splicing]] | ||
[[Category: Cytokine]] | [[Category: Cytokine]] | ||
[[Category: Endoplasmic reticulum]] | [[Category: Endoplasmic reticulum]] | ||
Current revision
Crystal structure of Interleukin 15 in complex with Interleukin 15 receptor alpha
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Categories: Large Structures | Lk3 transgenic mice | Kanagawa, O | Kishishita, S | Kukimoto-Niino, M | Murayama, K | Olsen, S K | Ota, N | Structural genomic | Shirouzu, M | Terada, T | Yokoyama, S | Alternative splicing | Cytokine | Endoplasmic reticulum | Glycoprotein | Golgi apparatus | Membrane | National project on protein structural and functional analyse | Nppsfa | Nucleus | Phosphorylation | Receptor | Rsgi | Secreted | Sushi | Transmembrane
