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Heat shock factor

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<StructureSection load='3hts' size='400' side='right' caption='Structure of monomer of the dimeric heat shock protein complex with DNA and glycerol (PDB entry [[3hts]])' scene='51/516471/Cv/3'>
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<StructureSection load='3hts' size='400' side='right' caption='Structure the dimeric heat shock protein complex with DNA and glycerol (PDB entry [[3hts]])' scene='51/516471/Cv/3'>
== Function ==
== Function ==
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'''Heat shock factor''' (HSF) are transcriptional activators of heat shock genes. HSF bind to heat shock sequence elements throughout the genome with a consensus array of three oppositely oriented sequence AGGAN and activate transcription. Each HSF monomer contains one C-terminal and 3 N-terminal leucine zippers. Two sequences flanking the N-terminal leucine zippers contain the consensus nuclear localization signal (NLS). The DNA-binding domain (DBD) of HSF lies in the N-terminal of the first NLS region<ref>PMID:8441385</ref>.
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'''Heat shock factor''' (HSF) are transcriptional activators of heat shock genes. HSF bind to heat shock sequence elements throughout the genome with a consensus array of three oppositely oriented sequence AGGAN and activate transcription. Each HSF monomer contains one C-terminal and 3 N-terminal leucine zippers. Two sequences flanking the N-terminal leucine zippers contain the consensus nuclear localization signal (NLS). The DNA-binding domain (DBD residues 193-281) of HSF lies in the N-terminal of the first NLS region<ref>PMID:8441385</ref>.
== Relevance ==
== Relevance ==
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== Structural highlights ==
== Structural highlights ==
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The DBD region of HSF shows <scene name='51/516471/Cv/2'>multiple protein-DNA interactions as well as water-mediated interactions</scene> <ref>PMID:10331875</ref>. Water molecules shown as red spheres.
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The DBD region of HSF shows <scene name='51/516471/Cv/4'>multiple protein-DNA interactions as well as water-mediated interactions</scene> <ref>PMID:10331875</ref>. Water molecules shown as red spheres.
==3D structures of heat shock factor==
==3D structures of heat shock factor==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[1hks]], [[1hkt]] – HSF DBD – ''Drosophila melanogaster'' – NMR<br />
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[[2ldu]] – hHSF-1 DBD residues 193-281 – human - NMR<br />
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[[2ldu]] – HSF DBD – human - NMR<br />
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[[5hdg]] – hHSF-1 DBD <br />
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[[5d5u]], [[5d5v]], [[5hdn]], [[7dcj]], [[7dcs]], [[7dct]] – hHSF-1 DBD + DNA<br />
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[[5hdk]] – hHSF-2 DBD <br />
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[[5d8k]], [[5d8l]], [[7dci]], [[7dcu]] – hHSF-2 DBD + DNA<br />
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[[6j6v]] – hHSF-4 DBD <br />
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[[6j6w]] – hHSF-4 DBD (mutant)<br />
[[2hts]], [[1fbu]] – KlHSF DBD – ''Kluyveromyces lactis''<br />
[[2hts]], [[1fbu]] – KlHSF DBD – ''Kluyveromyces lactis''<br />
[[3htf]], [[1fbq]], [[1fbs]] – KlHSF DBD (mutant) <br />
[[3htf]], [[1fbq]], [[1fbs]] – KlHSF DBD (mutant) <br />
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[[3hsf]] - KlHSF DBD (mutant) – NMR<br />
[[3hts]] – KlHSF DBD + DNA<br />
[[3hts]] – KlHSF DBD + DNA<br />
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[[1fyk]], [[1fyl]], [[1fym]] – KlHSF DBD (mutant) + DNA
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[[1fyk]], [[1fyl]], [[1fym]] – KlHSF DBD (mutant) + DNA<br />
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[[1hks]], [[1hkt]] – HSF DBD – ''Drosophila melanogaster'' – NMR<br />
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure the dimeric heat shock protein complex with DNA and glycerol (PDB entry 3hts)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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