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3kpt

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(New page: {{Seed}} 200px <!-- The line below this paragraph, containing "STRUCTURE_3kpt", creates the "Structure Box" on the page. You may change the PDB parameter (which se...)
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[[Image:3kpt.jpg|left|200px]]
 
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==Crystal structure of BcpA, the major pilin subunit of Bacillus cereus==
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The line below this paragraph, containing "STRUCTURE_3kpt", creates the "Structure Box" on the page.
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<StructureSection load='3kpt' size='340' side='right'caption='[[3kpt]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kpt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Baccr Baccr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KPT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3kpt| PDB=3kpt | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bcpA, BC_2508 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226900 BACCR])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kpt OCA], [https://pdbe.org/3kpt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kpt RCSB], [https://www.ebi.ac.uk/pdbsum/3kpt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kpt ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kp/3kpt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kpt ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Gram-positive bacteria elaborate pili and do so without the participation of folding chaperones or disulfide bond catalysts. Sortases, enzymes that cut pilin precursors, form covalent bonds that link pilin subunits and assemble pili on the bacterial surface. We determined the x-ray structure of BcpA, the major pilin subunit of Bacillus cereus. The BcpA precursor encompasses 2 Ig folds (CNA(2) and CNA(3)) and one jelly-roll domain (XNA) each of which synthesizes a single intramolecular amide bond. A fourth amide bond, derived from the Ig fold of CNA(1), is formed only after pilin subunits have been incorporated into pili. We report that the domains of pilin precursors have evolved to synthesize a discrete sequence of intramolecular amide bonds, thereby conferring structural stability and protease resistance to pili.
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===Crystal structure of BcpA, the major pilin subunit of Bacillus cereus===
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Intramolecular amide bonds stabilize pili on the surface of bacilli.,Budzik JM, Poor CB, Faull KF, Whitelegge JP, He C, Schneewind O Proc Natl Acad Sci U S A. 2009 Nov 10. PMID:19903875<ref>PMID:19903875</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19903875}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3kpt" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19903875 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19903875}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Baccr]]
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3KPT is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_cereus_atcc_14579 Bacillus cereus atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KPT OCA].
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[[Category: Large Structures]]
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[[Category: Budzik, J M]]
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==Reference==
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[[Category: He, C]]
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<ref group="xtra">PMID:19903875</ref><references group="xtra"/>
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[[Category: Poor, C B]]
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[[Category: Bacillus cereus atcc 14579]]
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[[Category: Schneewind, O]]
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[[Category: Budzik, J M.]]
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[[Category: He, C.]]
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[[Category: Poor, C B.]]
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[[Category: Schneewind, O.]]
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[[Category: Beta sheet]]
[[Category: Beta sheet]]
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[[Category: Cell adhesion]]
[[Category: Intramolecular amide bond]]
[[Category: Intramolecular amide bond]]
[[Category: Pilin subunit]]
[[Category: Pilin subunit]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 25 09:25:09 2009''
 

Current revision

Crystal structure of BcpA, the major pilin subunit of Bacillus cereus

PDB ID 3kpt

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