1oa5

From Proteopedia

(Difference between revisions)

Revision as of 07:10, 25 August 2021

The solution structure of bovine pancreatic trypsin inhibitor at high pressure

Structural highlights

1oa5 is a 1 chain structure with sequence from Bos taurus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1aal, 1b0c, 1bhc, 1bpi, 1bpt, 1bth, 1bti, 1bz5, 1bzx, 1cbw, 1d0d, 1eaw, 1ejm, 1f5r, 1f7z, 1fan, 1fy8, 1g6x, 1jv8, 1jv9, 1k6u, 1ld5, 1ld6, 1mtn, 1nag, 1oa6, 1pit, 1qlq, 1tpa, 2hex, 2kai, 2ptc, 2tgp, 2tpi, 3btd, 3bte, 3btf, 3btg, 3bth, 3btk, 3btm, 3btq, 3btt, 3btw, 3tgi, 3tgj, 3tgk, 3tpi, 4pti, 4tpi, 5pti, 6pti, 7pti, 8pti, 9pti
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BPT1_BOVIN] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The solution structure of bovine pancreatic trypsin inhibitor (BPTI) at a pressure of 2 kbar is presented. The structure was calculated as a change from an energy-minimized low-pressure structure, using (1)H chemical shifts as restraints. The structure has changed by 0.24 A RMS, and has almost unchanged volume. The largest changes as a result of pressure are in the loop 10-16, which contains the active site of BPTI, and residues 38-42, which are adjacent to buried water molecules. Hydrogen bonds are compressed by 0.029 +/- 0.117 A, with the longer hydrogen bonds, including those to internal buried water molecules, being compressed more. The hydrophobic core is also compressed, largely from reduction of packing defects. The parts of the structure that have the greatest change are close to buried water molecules, thus highlighting the importance of water molecules as the nucleation sites for volume fluctuation of proteins in native conditions.

The solution structure of bovine pancreatic trypsin inhibitor at high pressure.,Williamson MP, Akasaka K, Refaee M Protein Sci. 2003 Sep;12(9):1971-9. PMID:12930996^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Williamson MP, Akasaka K, Refaee M. The solution structure of bovine pancreatic trypsin inhibitor at high pressure. Protein Sci. 2003 Sep;12(9):1971-9. PMID:12930996

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1oa5"

@@ Line 3: / Line 3: @@
 <StructureSection load='1oa5' size='340' side='right'caption='[[1oa5]], [[NMR_Ensembles_of_Models | 3 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1oa5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OA5 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1oa5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OA5 FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1aal|1aal]], [[1b0c|1b0c]], [[1bhc|1bhc]], [[1bpi|1bpi]], [[1bpt|1bpt]], [[1bth|1bth]], [[1bti|1bti]], [[1bz5|1bz5]], [[1bzx|1bzx]], [[1cbw|1cbw]], [[1d0d|1d0d]], [[1eaw|1eaw]], [[1ejm|1ejm]], [[1f5r|1f5r]], [[1f7z|1f7z]], [[1fan|1fan]], [[1fy8|1fy8]], [[1g6x|1g6x]], [[1jv8|1jv8]], [[1jv9|1jv9]], [[1k6u|1k6u]], [[1ld5|1ld5]], [[1ld6|1ld6]], [[1mtn|1mtn]], [[1nag|1nag]], [[1oa6|1oa6]], [[1pit|1pit]], [[1qlq|1qlq]], [[1tpa|1tpa]], [[2hex|2hex]], [[2kai|2kai]], [[2ptc|2ptc]], [[2tgp|2tgp]], [[2tpi|2tpi]], [[3btd|3btd]], [[3bte|3bte]], [[3btf|3btf]], [[3btg|3btg]], [[3bth|3bth]], [[3btk|3btk]], [[3btm|3btm]], [[3btq|3btq]], [[3btt|3btt]], [[3btw|3btw]], [[3tgi|3tgi]], [[3tgj|3tgj]], [[3tgk|3tgk]], [[3tpi|3tpi]], [[4pti|4pti]], [[4tpi|4tpi]], [[5pti|5pti]], [[6pti|6pti]], [[7pti|7pti]], [[8pti|8pti]], [[9pti|9pti]]</td></tr>
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1aal|1aal]], [[1b0c|1b0c]], [[1bhc|1bhc]], [[1bpi|1bpi]], [[1bpt|1bpt]], [[1bth|1bth]], [[1bti|1bti]], [[1bz5|1bz5]], [[1bzx|1bzx]], [[1cbw|1cbw]], [[1d0d|1d0d]], [[1eaw|1eaw]], [[1ejm|1ejm]], [[1f5r|1f5r]], [[1f7z|1f7z]], [[1fan|1fan]], [[1fy8|1fy8]], [[1g6x|1g6x]], [[1jv8|1jv8]], [[1jv9|1jv9]], [[1k6u|1k6u]], [[1ld5|1ld5]], [[1ld6|1ld6]], [[1mtn|1mtn]], [[1nag|1nag]], [[1oa6|1oa6]], [[1pit|1pit]], [[1qlq|1qlq]], [[1tpa|1tpa]], [[2hex|2hex]], [[2kai|2kai]], [[2ptc|2ptc]], [[2tgp|2tgp]], [[2tpi|2tpi]], [[3btd|3btd]], [[3bte|3bte]], [[3btf|3btf]], [[3btg|3btg]], [[3bth|3bth]], [[3btk|3btk]], [[3btm|3btm]], [[3btq|3btq]], [[3btt|3btt]], [[3btw|3btw]], [[3tgi|3tgi]], [[3tgj|3tgj]], [[3tgk|3tgk]], [[3tpi|3tpi]], [[4pti|4pti]], [[4tpi|4tpi]], [[5pti|5pti]], [[6pti|6pti]], [[7pti|7pti]], [[8pti|8pti]], [[9pti|9pti]]</div></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oa5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oa5 OCA], [http://pdbe.org/1oa5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oa5 RCSB], [http://www.ebi.ac.uk/pdbsum/1oa5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1oa5 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oa5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oa5 OCA], [https://pdbe.org/1oa5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oa5 RCSB], [https://www.ebi.ac.uk/pdbsum/1oa5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oa5 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN]] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
+[[https://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN]] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

1oa5

From Proteopedia

Revision as of 07:10, 25 August 2021

The solution structure of bovine pancreatic trypsin inhibitor at high pressure

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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