1f6m

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[[Image:1f6m.gif|left|200px]]
[[Image:1f6m.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1f6m |SIZE=350|CAPTION= <scene name='initialview01'>1f6m</scene>, resolution 2.95&Aring;
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The line below this paragraph, containing "STRUCTURE_1f6m", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=3AA:3-AMINOPYRIDINE-ADENINE+DINUCLEOTIDE+PHOSPHATE'>3AA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1f6m| PDB=1f6m | SCENE= }}
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|RELATEDENTRY=[[1tdf|1TDF]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f6m OCA], [http://www.ebi.ac.uk/pdbsum/1f6m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1f6m RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THIOREDOXIN REDUCTASE, THIOREDOXIN, AND THE NADP+ ANALOG, AADP+'''
'''CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THIOREDOXIN REDUCTASE, THIOREDOXIN, AND THE NADP+ ANALOG, AADP+'''
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[[Category: Lennon, B W.]]
[[Category: Lennon, B W.]]
[[Category: Ludwig, M L.]]
[[Category: Ludwig, M L.]]
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[[Category: alternate conformation]]
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[[Category: Alternate conformation]]
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[[Category: domain motion]]
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[[Category: Domain motion]]
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[[Category: electron transport]]
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[[Category: Electron transport]]
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[[Category: fad]]
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[[Category: Fad]]
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[[Category: nadp]]
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[[Category: Nadp]]
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[[Category: redox-active center]]
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[[Category: Redox-active center]]
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[[Category: ternary complex]]
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[[Category: Ternary complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:57:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:16:57 2008''
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Revision as of 12:57, 2 May 2008

Image:1f6m.gif

Template:STRUCTURE 1f6m

CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THIOREDOXIN REDUCTASE, THIOREDOXIN, AND THE NADP+ ANALOG, AADP+


Overview

In thioredoxin reductase (TrxR) from Escherichia coli, cycles of reduction and reoxidation of the flavin adenine dinucleotide (FAD) cofactor depend on rate-limiting rearrangements of the FAD and NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) domains. We describe the structure of the flavin-reducing conformation of E. coli TrxR at a resolution of 3.0 angstroms. The orientation of the two domains permits reduction of FAD by NADPH and oxidation of the enzyme dithiol by the protein substrate, thioredoxin. The alternate conformation, described by Kuriyan and co-workers, permits internal transfer of reducing equivalents from reduced FAD to the active-site disulfide. Comparison of these structures demonstrates that switching between the two conformations involves a "ball-and-socket" motion in which the pyridine nucleotide-binding domain rotates by 67 degrees.

About this Structure

1F6M is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Twists in catalysis: alternating conformations of Escherichia coli thioredoxin reductase., Lennon BW, Williams CH Jr, Ludwig ML, Science. 2000 Aug 18;289(5482):1190-4. PMID:10947986 Page seeded by OCA on Fri May 2 15:57:53 2008

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