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1qe4

From Proteopedia

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{{Theoretical_model}}
{{Theoretical_model}}
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[[Image:1qe4.png|left|200px]]
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==BUILDING A REPLISOME FROM INTERACTING PIECES: SLIDING CLAMP COMPLEXED TO A PEPTIDE FROM DNA POLYMERASE AND A POLYMERASE EDITING COMPLEX==
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<StructureSection load='1qe4' size='340' side='right'caption='[[1qe4]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QE4 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qe4 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1qe4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qe4 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have solved the crystal structures of the bacteriophage RB69 sliding clamp, its complex with a peptide essential for DNA polymerase interactions, and the DNA polymerase complexed with primer-template DNA. The editing complex structure shows a partially melted duplex DNA exiting from the exonuclease domain at an unexpected angle and significant changes in the protein structure. The clamp complex shows the C-terminal 11 residues of polymerase bound in a hydrophobic pocket, and it allows docking of the editing and clamp structures together. The peptide binds to the sliding clamp at a position identical to that of a replication inhibitor peptide bound to PCNA, suggesting that the replication inhibitor protein p21CIP1 functions by competing with eukaryotic polymerases for the same binding pocket on the clamp.
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{{STRUCTURE_1qe4| PDB=1qe4 | SCENE= }}
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Building a replisome from interacting pieces: sliding clamp complexed to a peptide from DNA polymerase and a polymerase editing complex.,Shamoo Y, Steitz TA Cell. 1999 Oct 15;99(2):155-66. PMID:10535734<ref>PMID:10535734</ref>
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===BUILDING A REPLISOME FROM INTERACTING PIECES: SLIDING CLAMP COMPLEXED TO A PEPTIDE FROM DNA POLYMERASE AND A POLYMERASE EDITING COMPLEX===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_10535734}}
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<div class="pdbe-citations 1qe4" style="background-color:#fffaf0;"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:010535734</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Theoretical Model]]
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[[Category: Large Structures]]
[[Category: Shamoo, Y]]
[[Category: Shamoo, Y]]
[[Category: Steitz, T A]]
[[Category: Steitz, T A]]

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

BUILDING A REPLISOME FROM INTERACTING PIECES: SLIDING CLAMP COMPLEXED TO A PEPTIDE FROM DNA POLYMERASE AND A POLYMERASE EDITING COMPLEX

PDB ID 1qe4

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