1f8q

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[[Image:1f8q.gif|left|200px]]
[[Image:1f8q.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1f8q |SIZE=350|CAPTION= <scene name='initialview01'>1f8q</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1f8q", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PTD:PENTANEDIAL'>PTD</scene>, <scene name='pdbligand=XYS:XYLOPYRANOSE'>XYS</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1f8q| PDB=1f8q | SCENE= }}
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|RELATEDENTRY=[[1mri|1mri]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f8q OCA], [http://www.ebi.ac.uk/pdbsum/1f8q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1f8q RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF ALPHA-MOMORCHARIN IN ACETONITRILE-WATER MIXTURE'''
'''CRYSTAL STRUCTURE OF ALPHA-MOMORCHARIN IN ACETONITRILE-WATER MIXTURE'''
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[[Category: Momordica charantia]]
[[Category: Momordica charantia]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: rRNA N-glycosylase]]
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[[Category: RRNA N-glycosylase]]
[[Category: Huang, Q.]]
[[Category: Huang, Q.]]
[[Category: Qian, M.]]
[[Category: Qian, M.]]
[[Category: Tang, Y.]]
[[Category: Tang, Y.]]
[[Category: Zhu, G.]]
[[Category: Zhu, G.]]
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[[Category: momorcharin]]
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[[Category: Momorcharin]]
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[[Category: organic slovent]]
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[[Category: Organic slovent]]
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[[Category: ribosome-inactivating protein]]
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[[Category: Ribosome-inactivating protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:02:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:18:02 2008''
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Revision as of 13:02, 2 May 2008

Image:1f8q.gif

Template:STRUCTURE 1f8q

CRYSTAL STRUCTURE OF ALPHA-MOMORCHARIN IN ACETONITRILE-WATER MIXTURE


Overview

Crystals of alpha-momorcharin (MMC) were cross-linked and soaked in an 80% acetonitrile--water mixture and X-ray data were collected to 2.2 A resolution. MMC is a ribosome-inactivating protein with a sugar chain on Asn-227. In previous studies, the whole conformation of the sugar chain could not be obtained in the aqueous system. Here the structure of MMC in a low water system is shown to be similar to the native one, but the sugar chain on Asn-227 is defined by the electron density map. Several oxygen atoms of the oligosaccharide formed intramolecular hydrogen bonds to the protein moiety. The conformation of the residues in the active center is similar to that in the aqueous system. Our results show conformational alteration of the tetrasaccharide of MMC in organic media. They indicate that the oligosaccharides are more rigid in organic solvents. X-ray determination in organic media may be used to solve some structures of oligosaccharides linked to glycoproteins.

About this Structure

1F8Q is a Single protein structure of sequence from Momordica charantia. Full crystallographic information is available from OCA.

Reference

Crystal structure of alpha-momorcharin in 80% acetonitrile--water mixture., Zhu G, Huang Q, Qian M, Tang Y, Biochim Biophys Acta. 2001 Jul 9;1548(1):152-8. PMID:11451448 Page seeded by OCA on Fri May 2 16:02:09 2008

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