Histone deacetylase 3D structures
From Proteopedia
(Difference between revisions)
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**[[3hgq]], [[3hgt]] – hHDAC1 subunit 3<br /> | **[[3hgq]], [[3hgt]] – hHDAC1 subunit 3<br /> | ||
**[[5icn]] – hHDAC1 + MTA1 + peptide<br /> | **[[5icn]] – hHDAC1 + MTA1 + peptide<br /> | ||
| + | **[[7ao8]], [[7ao9]] – hHDAC1 + MTA1 + MBD2 – Cryo EM<br /> | ||
| + | **[[7aoa]] – hHDAC1 + MTA1 + MBD2 + RBBP4 – Cryo EM<br /> | ||
**[[6z2j]], [[6z2k]] – hHDAC1 + DNTTIP1 + Midac deacetylase – Cryo EM<br /> | **[[6z2j]], [[6z2k]] – hHDAC1 + DNTTIP1 + Midac deacetylase – Cryo EM<br /> | ||
**[[5j8j]] – yHDAC1 residues 457-698 – yeast<br /> | **[[5j8j]] – yHDAC1 residues 457-698 – yeast<br /> | ||
| + | **[[6z6f]], [[6z6h]], [[6z6o]], [[6z6p]] – yHDAC1 – Cryo EM<br /> | ||
*HDAC2 | *HDAC2 | ||
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**[[3max]] – hHDAC2 + amide derivative <br /> | **[[3max]] – hHDAC2 + amide derivative <br /> | ||
**[[4lxz]], [[6g3o]] – hHDAC2 core domain + SAHA<br /> | **[[4lxz]], [[6g3o]] – hHDAC2 core domain + SAHA<br /> | ||
| - | **[[4ly1]], [[5iwg]], [[5ix0]], [[6wbz]], [[6wbw]], [[6xdm]], [[6xeb]], [[6xec]] – hHDAC2 core domain + inhibitor<br /> | + | **[[4ly1]], [[5iwg]], [[5ix0]], [[6wbz]], [[6wbw]], [[6xdm]], [[6xeb]], [[6xec]], [[7js8]], [[7kbh]], [[7kbg]], [[7ltg]], [[7ltk]], [[7ltl]], [[7mot]], [[7mox]], [[7moy]] – hHDAC2 core domain + inhibitor<br /> |
| + | **[[6whn]], [[6who]], [[6whq]], [[6whz]], [[6wi3]], [[7mos]], [[7moz]] – hHDAC2 core domain + peptide macrocycle<br /> | ||
*HDAC3 | *HDAC3 | ||
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**[[4qa1]], [[4qa2]], [[4qa3]], [[4qa4]] - hHDAC8 (mutant) + inhibitor<br /> | **[[4qa1]], [[4qa2]], [[4qa3]], [[4qa4]] - hHDAC8 (mutant) + inhibitor<br /> | ||
**[[1t64]], [[3f0r]], [[5ths]] – hHDAC8 + trichostatin A <br /> | **[[1t64]], [[3f0r]], [[5ths]] – hHDAC8 + trichostatin A <br /> | ||
| - | **[[5tht]], [[5thu]], [[5thv]], [[5dc5]], [[5d1b]] - hHDAC8 (mutant) + amide derivative<br /> | + | **[[5tht]], [[5thu]], [[5thv]], [[5dc5]], [[5d1b]], [[7jvw]] - hHDAC8 (mutant) + amide derivative<br /> |
**[[1t67]], [[1w22]], [[1vkg]], [[3f07]], [[6oda]], [[6odb]], [[6odc]] - hHDAC8 + amide derivative<br /> | **[[1t67]], [[1w22]], [[1vkg]], [[3f07]], [[6oda]], [[6odb]], [[6odc]] - hHDAC8 + amide derivative<br /> | ||
**[[1t69]] - hHDAC8 + SAHA<br /> | **[[1t69]] - hHDAC8 + SAHA<br /> | ||
| - | **[[4qa0]] - hHDAC8 (mutant) + SAHA<br /> | + | **[[4qa0]], [[7jvu]] - hHDAC8 (mutant) + SAHA<br /> |
**[[5fcw]], [[5fue]] - hHDAC8 + hydroxamate<br /> | **[[5fcw]], [[5fue]] - hHDAC8 + hydroxamate<br /> | ||
**[[5vi6]] - hHDAC8 + trapoxin A<br /> | **[[5vi6]] - hHDAC8 + trapoxin A<br /> | ||
**[[2v5w]] – hHDAC8 + tripeptide substrate<br /> | **[[2v5w]] – hHDAC8 + tripeptide substrate<br /> | ||
| - | **[[4qa5]], [[4qa6]], [[4qa7]], [[3ewf]], [[5dc8]], [[5dc7]], [[5dc6]], [[5d1d]], [[5d1c]] - hHDAC8 (mutant) + tetrapeptide substrate<br /> | + | **[[4qa5]], [[4qa6]], [[4qa7]], [[3ewf]], [[5dc8]], [[5dc7]], [[5dc6]], [[5d1d]], [[5d1c]], [[7jvv]], [[7p3s]] - hHDAC8 (mutant) + tetrapeptide substrate<br /> |
**[[3rqd]] - hHDAC8 + largazole<br /> | **[[3rqd]] - hHDAC8 + largazole<br /> | ||
**[[4rn0]], [[4rn1]], [[4rn2]] - hHDAC8 (mutant) + largazole analog<br /> | **[[4rn0]], [[4rn1]], [[4rn2]] - hHDAC8 (mutant) + largazole analog<br /> | ||
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**[[2v5x]] - hHDAC8 (mutant) + octanediamide derivative<br /> | **[[2v5x]] - hHDAC8 (mutant) + octanediamide derivative<br /> | ||
**[[4bz5]] – SmHDAC8 – ''Schistosoma mansoni''<br /> | **[[4bz5]] – SmHDAC8 – ''Schistosoma mansoni''<br /> | ||
| - | **[[4bz7]], [[4bz8]], [[4bz9]], [[4cqf]], [[6hsz]], [[6ht8]], [[6htg]], [[6hth]], [[6hti]], [[6htt]], [[6htz]], [[6hu0]], [[6hu1]], [[6hu2]], [[6hu3]], [[6hsh]], [[6hrq]], [[6hqy]], [[6tld]] – SmHDAC8 + inhibitor<br /> | + | **[[4bz7]], [[4bz8]], [[4bz9]], [[4cqf]], [[6hsz]], [[6ht8]], [[6htg]], [[6hth]], [[6hti]], [[6htt]], [[6htz]], [[6hu0]], [[6hu1]], [[6hu2]], [[6hu3]], [[6hsh]], [[6hrq]], [[6hqy]], [[6tld]], [[7p3s]] – SmHDAC8 + inhibitor<br /> |
**[[6hsk]], [[6hsf]], [[6hsg]] – SmHDAC8 (mutant) + inhibitor<br /> | **[[6hsk]], [[6hsf]], [[6hsg]] – SmHDAC8 (mutant) + inhibitor<br /> | ||
**[[4bz6]], [[6gxw]], [[6gxu]], [[6gxa]], [[6gx3]], [[6fu1]] – SmHDAC8 + SAHA derivative<br /> | **[[4bz6]], [[6gxw]], [[6gxu]], [[6gxa]], [[6gx3]], [[6fu1]] – SmHDAC8 + SAHA derivative<br /> | ||
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*HDAC10 or polyamine deacetylase 10 | *HDAC10 or polyamine deacetylase 10 | ||
| - | **[[6ufn]], [[6ufo]], [[6uhu]], [[6uhv]], [[6uii]], [[6uij]], [[6uil]], [[6uim]], [[6wbq]], [[6wdv]], [[6wdw]], [[6wdx]], [[6wdy]] – zHDAC10 + inhibitor | + | **[[7kuv]] – zHDAC10 - zebrafish<br /> |
| - | **[[6vnq]] – zHDAC10 (mutant) + inhibitor <br /> | + | **[[6ufn]], [[6ufo]], [[6uhu]], [[6uhv]], [[6uii]], [[6uij]], [[6uil]], [[6uim]], [[6wbq]], [[6wdv]], [[6wdw]], [[6wdx]], [[6wdy]] – zHDAC10 + inhibitor<br /> |
| + | **[[6vnq]], [[7kuq]], [[7kur]], [[7kus]], [[7kut]] – zHDAC10 (mutant) + inhibitor <br /> | ||
*HDAC | *HDAC | ||
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**[[5kh3]], [[5kh7]], [[5kh9]], [[5b8d]], [[6ce6]], [[6ce8]], [[6cea]], [[6cec]], [[6ced]], [[6cee]], [[6cef]], [[5wpb]], [[5wbn]] – hHDAC6 zinc finger + inhibitor<br /> | **[[5kh3]], [[5kh7]], [[5kh9]], [[5b8d]], [[6ce6]], [[6ce8]], [[6cea]], [[6cec]], [[6ced]], [[6cee]], [[6cef]], [[5wpb]], [[5wbn]] – hHDAC6 zinc finger + inhibitor<br /> | ||
**[[5eem]] – zHDAC6 catalytic domain<br /> | **[[5eem]] – zHDAC6 catalytic domain<br /> | ||
| - | **[[6cgp]], [[5wgm]], [[5wgl]], [[5wgi]], [[5wgk]], [[5g0j]], [[5g0i]], [[5g0h]], [[5g0g]], [[5g0f]], [[5efh]], [[5efg]], [[5efb]], [[5ef7]], [[5ef8]], [[5een]], [[5eek]], [[5eef]], [[6mr5]], [[6dvo]], [[6dvn]], [[6dvm]], [[6dvl]], [[6cw8]], [[6pye]], [[6pzo]], [[6pzr]], [[6pzs]], [[6pzu]], [[6q0z]], [[6r0k]], [[6thv]], [[6uo2]], [[6uo3]], [[6uo5]], [[6vnr]] – zHDAC6 catalytic domain + inhibitor <br /> | + | **[[6cgp]], [[5wgm]], [[5wgl]], [[5wgi]], [[5wgk]], [[5g0j]], [[5g0i]], [[5g0h]], [[5g0g]], [[5g0f]], [[5efh]], [[5efg]], [[5efb]], [[5ef7]], [[5ef8]], [[5een]], [[5eek]], [[5eef]], [[6mr5]], [[6dvo]], [[6dvn]], [[6dvm]], [[6dvl]], [[6cw8]], [[6pye]], [[6pzo]], [[6pzr]], [[6pzs]], [[6pzu]], [[6q0z]], [[6r0k]], [[6tcy]], [[6thv]], [[6uo2]], [[6uo3]], [[6uo5]], [[6uo7]], [[6v79]], [[6v7a]], [[6vnr]], [[6zw1]], [[7jom]] – zHDAC6 catalytic domain + inhibitor <br /> |
| - | **[[6uo4]], [[6uo7]], [[6uob]], [[6uoc]] – zHDAC6 catalytic domain (mutant) + inhibitor <br /> | + | **[[6uo4]], [[6uo7]], [[6uob]], [[6uoc]], [[6wyo]] – zHDAC6 catalytic domain (mutant) + inhibitor <br /> |
**[[5eei]], [[6css]], [[6csr]], [[6csq]], [[6csp]], [[5w5k]] – zHDAC6 catalytic domain + SAHA derivative<br /> | **[[5eei]], [[6css]], [[6csr]], [[6csq]], [[6csp]], [[5w5k]] – zHDAC6 catalytic domain + SAHA derivative<br /> | ||
| + | **[[6wyp]], [[6wyq]] – zHDAC6 catalytic domain (mutant) + SAHA derivative<br /> | ||
| + | **[[6wsj]] – zHDAC6 catalytic domain + peptide <br /> | ||
**[[5efn]], [[5efk]], [[53fj]] – zHDAC6 catalytic domain (mutant) + peptide <br /> | **[[5efn]], [[5efk]], [[53fj]] – zHDAC6 catalytic domain (mutant) + peptide <br /> | ||
Revision as of 09:11, 23 September 2021
3D Structures of histone deacetylase
Updated on 23-September-2021
