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Integrin 3D structures

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Line 73: Line 73:
**[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br />
**[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br />
-
*IG α-5 (CD49e) β-3 (CD61) ectodomain
+
*IG α-5 (CD49e) + IG β-3 (CD61) ectodomain
**[[3ije]], [[1m1x]], [[4g1e]], [[4g1m]], [[1u8c]] – hIG + cation<br />
**[[3ije]], [[1m1x]], [[4g1e]], [[4g1m]], [[1u8c]] – hIG + cation<br />
Line 81: Line 81:
**[[1l5g]] - hIG + tripeptide + Mn<br />
**[[1l5g]] - hIG + tripeptide + Mn<br />
-
*IG α-5 β-6
+
*IG α-5 + IG β-6
**[[4um8]] – hIG headpiece (mutant) + Ni<br />
**[[4um8]] – hIG headpiece (mutant) + Ni<br />
Line 88: Line 88:
**[[5neu]], [[5net]], [[5ner]], [[5nem]] – hIG headpiece + foot-and-mouth virus – Cryo EM<br />
**[[5neu]], [[5net]], [[5ner]], [[5nem]] – hIG headpiece + foot-and-mouth virus – Cryo EM<br />
**[[5ffo]] – hIG headpiece + TGF-beta-1<br />
**[[5ffo]] – hIG headpiece + TGF-beta-1<br />
 +
 +
*IG α-6 + IG β-1
 +
**[[7ceb]], [[7cec]] – hIG headpiece + laminin + Mg<br />
 +
 +
*IG α-L
 +
 +
**[[1lfa]] - hIG I domain + Mn <br />
 +
**[[1zon]], [[4ixd]] - hIG I domain <br />
 +
**[[1mqa]] - hIG I domain (mutant) <br />
 +
**[[1zoo]], [[1zop]], [[3f74]] - hIG I domain + Mg <br />
 +
**[[1mq9]] - hIG I domain (mutant) + Mn <br />
 +
**[[1mjn]] - hIG I domain (mutant) + Mg <br />
 +
**[[2k8o]] – hIG cytoplasmic domain (mutant) – NMR <br />
 +
**[[5e6s]], [[5e6r]] – hIG AI, headpiece,pocket domains + Mg<br />
 +
**[[2m3e]] – hIG transmembrane domain - NMR<br />
 +
 +
*IG α-L complexes
 +
 +
**[[1cqp]] - hIG I domain + lovastatin + Mg <br />
 +
**[[1mq8]], [[3bn3]], [[3tcx]] - hIG I domain (mutant) + intracellular adhesion molecule + Mg <br />
 +
**[[1t0p]] - hIG I domain + intracellular adhesion molecule-3 + Mg<br />
 +
**[[1rd4]], [[2ica]], [[3bqm]], [[3bqn]], [[3e2m]] - hIG I domain + inhibitor<br />
 +
**[[2o7n]], [[3m6f]] - hIG I domain + antagonist<br />
 +
**[[1xdd]], [[1xdg]], [[1xuo]] - hIG I domain + inhibitor + Mg<br />
 +
**[[3f78]] - hIG I domain + anesthetic + Mg<br />
 +
**[[3eoa]], [[3eob]] - hIG I domain + antibody<br />
 +
**[[3hi6]] - hIG I domain (mutant) + antibody + Mn<br />
 +
 +
*IG α-M
 +
 +
**[[1idn]], [[1na5]] - hIG<br />
 +
**[[1mf7]] - hIG (mutant) <br />
 +
**[[1bho]] - hIG + Mg<br />
 +
**[[1bhq]] - hIG + Cd<br />
 +
**[[1m1u]] - hIG (mutant) + Ca<br />
 +
**[[1n9z]] - hIG (mutant) + Mg<br />
 +
**[[3q3g]], [[3qa3]] – hIG + antibody<br />
 +
**[[4m76]] – hIG + complement C3<br />
 +
**[[2lke]], [[2lkj – hIG cytoplasmic domain – NMR<br />
 +
**[[4xw2]] – hIG + simvastatin<br />
 +
**[[6rhv]], [[6rhw]] – hIG + cytolysin<br />
 +
*IG α-L
*IG α-L
Line 95: Line 137:
**[[2m3e]] – hIG transmembrane domain - NMR<br />
**[[2m3e]] – hIG transmembrane domain - NMR<br />
-
*IG α-L β-2
+
*IG α-L + IG β-2
**[[5e6u]] – hIG headpiece (mutant) + Ni<br />
**[[5e6u]] – hIG headpiece (mutant) + Ni<br />
-
*IG α-V β-3
+
*IG α-V + IG β-3
**[[6mk0]] – hIG + antagonist<br />
**[[6mk0]] – hIG + antagonist<br />
Line 106: Line 148:
**[[6naj]] – hIG + fibronectin<br />
**[[6naj]] – hIG + fibronectin<br />
-
*IG α-V β-8
+
*IG α-V + IG β-8
**[[6djp]], [[6ujb]], [[6ujc]] – hIG + antibody – Cryo EM<br />
**[[6djp]], [[6ujb]], [[6ujc]] – hIG + antibody – Cryo EM<br />
Line 116: Line 158:
**[[2luv]] – hIG cytoplasmic domain – NMR<BR />
**[[2luv]] – hIG cytoplasmic domain – NMR<BR />
 +
**[[1n3y]] – hIG domain I (mutant)<br />
-
*IG α-X β-2 (CD18)
+
*IG α-X + IG β-2 (CD18)
**[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg<br />
**[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg<br />
Line 139: Line 182:
**[[2l1c]] – hIG cytoplasmic tail + SHC<br />
**[[2l1c]] – hIG cytoplasmic tail + SHC<br />
**[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br />
**[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br />
 +
**[[6bxb]], [[6bxf]] – hIG/hIG α-L <br />
*IG β-4 (CD104; Gp150)
*IG β-4 (CD104; Gp150)

Revision as of 08:59, 5 October 2021

3D structures of integrin

Updated on 05-October-2021 {{#tree:id=OrganizedByTopic|openlevels=0|

  • IG CR3
    • 1ido – hIG I domain + Mg – human
    • 1jlm - hIG I domain + Mn
  • IG α-1 (CD49a)
    • 4a0q - hIG I domain (mutant) + Mg
    • 2l8s - hIG transmembrane domain – NMR
    • 5hgj - hIG VWFA domain
    • 2m32 - hIG I domain + collagen peptide
    • 1ck4 - rIG I domain – rat
    • 1mhp - rIG I domain (mutant) + antibody + Mn
    • 2b2x - rIG I domain (mutant) + antibody + Mg
  • IG α-2 (CD49b)
  • IG α-2b
    • 2k1a - hIG transmembrane domain – NMR
  • IG α-1 + IG β-1 (CD49a-CD49b)
    • 1qc5, 1qcy - hIG I domain (mutant) + Mg
    • 1pt6 - hIG I domain + Mg
  • IG α-2 (CD49b) + IG β
    • 5hj2 - hIG I domain
    • 1aox - hIG I domain (mutant) + Mg
    • 2k1a - hIG transmembrane domain – NMR
  • IG α-2b + IG β-3 (CD61)
  • IG α-4
    • 4irz - hIG + antibody
  • IG α-4 (CD49d) + IG β-7
    • 3v4p - hIG headpiece (mutant) + antibody + Mg
    • 3v4v - hIG headpiece (mutant) + antibody + inhibitor + Mg
  • IG α-5 (CD49e) + IG β-1 (CD29)
    • 7nxd – hIG + Mg – Cryo-EM
    • 7nwl – hIG + fibronectin + laminin – Cryo-EM
    • 4wjk - hIG headpiece (mutant) + Mg
    • 4wk0, 4wk2, 4wk4 - hIG headpiece (mutant) + peptide + Mg
    • 3vi3 - hIG headpiece + antibody + Mg
    • 3vi4 - hIG headpiece + antibody + peptide + Mg
  • IG α-5 (CD49e) + IG β-3 (CD61) ectodomain
  • IG α-5 + IG β-6
    • 4um8 – hIG headpiece (mutant) + Ni
    • 5ffg – hIG headpiece + Ca
    • 4um9 – hIG headpiece (mutant) + Mg + transforming growth factor β 3
    • 5neu, 5net, 5ner, 5nem – hIG headpiece + foot-and-mouth virus – Cryo EM
    • 5ffo – hIG headpiece + TGF-beta-1
  • IG α-6 + IG β-1
    • 7ceb, 7cec – hIG headpiece + laminin + Mg
  • IG α-L
    • 1lfa - hIG I domain + Mn
    • 1zon, 4ixd - hIG I domain
    • 1mqa - hIG I domain (mutant)
    • 1zoo, 1zop, 3f74 - hIG I domain + Mg
    • 1mq9 - hIG I domain (mutant) + Mn
    • 1mjn - hIG I domain (mutant) + Mg 
**2k8o – hIG cytoplasmic domain (mutant) – NMR
    • 5e6s, 5e6r – hIG AI, headpiece,pocket domains + Mg
    • 2m3e – hIG transmembrane domain - NMR
  • IG α-L complexes
    • 1cqp - hIG I domain + lovastatin + Mg
    • 1mq8, 3bn3, 3tcx - hIG I domain (mutant) + intracellular adhesion molecule + Mg
    • 1t0p - hIG I domain + intracellular adhesion molecule-3 + Mg
    • 1rd4, 2ica, 3bqm, 3bqn, 3e2m - hIG I domain + inhibitor
    • 2o7n, 3m6f - hIG I domain + antagonist
    • 1xdd, 1xdg, 1xuo - hIG I domain + inhibitor + Mg
    • 3f78 - hIG I domain + anesthetic + Mg
    • 3eoa, 3eob - hIG I domain + antibody
    • 3hi6 - hIG I domain (mutant) + antibody + Mn
  • IG α-M
    • 1idn, 1na5 - hIG
    • 1mf7 - hIG (mutant)
    • 1bho - hIG + Mg
    • 1bhq - hIG + Cd
    • 1m1u - hIG (mutant) + Ca
    • 1n9z - hIG (mutant) + Mg
    • 3q3g, 3qa3 – hIG + antibody
    • 4m76 – hIG + complement C3
    • 2lke, [[2lkj – hIG cytoplasmic domain – NMR
    • 4xw2 – hIG + simvastatin
    • 6rhv, 6rhw – hIG + cytolysin


  • IG α-L
    • 4ixd – hIG I domain
    • 5e6s, 5e6r – hIG AI, headpiece,pocket domains + Mg
    • 2m3e – hIG transmembrane domain - NMR
  • IG α-L + IG β-2
    • 5e6u – hIG headpiece (mutant) + Ni
  • IG α-V + IG β-3
    • 6mk0 – hIG + antagonist
    • 6msl – hIG + cysteine knot protein
    • 6msu – hIG + EETI-II
    • 6naj – hIG + fibronectin
  • IG α-V + IG β-8
    • 6djp, 6ujb, 6ujc – hIG + antibody – Cryo EM
    • 6om1 – hIG (mutant)
    • 6om2 – hIG (mutant) + Protgf-b1 RGD peptide
    • 6uja – hIG + Protgf-b1 RGD – Cryo EM
  • IG α-X
    • 2luv – hIG cytoplasmic domain – NMR
    • 1n3y – hIG domain I (mutant)
  • IG α-X + IG β-2 (CD18)
  • IG β-1D
    • 3g9w – hIG cytoplasmic tail + talin 2 F2-F3 domain
  • IG β-2 (CD18)
    • 2p26, 2p28, 5e6w – hIG phe2 + phe3 domains
    • 1yuk – hIG chain A PSI domain + chain B I-EGF domain
    • 5zaz – hIG transmembrane domain - NMR
  • IG β-3 (CD61)
    • 1s4x, 2kv9, 2ljd, 2lje, 2ljf – hIG cytoplasmic domain – NMR
    • 2rmz, 2rn0 – hIG transmembrane domain – NMR
    • 2l91 - hIG transmembrane domain (mutant) – NMR
    • 2l1c – hIG cytoplasmic tail + SHC
    • 2mtp – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain
    • 6bxb, 6bxf – hIG/hIG α-L
  • IG β-4 (CD104; Gp150)
    • 2f7q, 3f7r, 1qg3, 3f7q, 4wtw, 4wtx - hIG fibronectin type III domain
    • 2yrz – hIG fibronectin type III domain – NMR
    • 3f7p, 4q58 - hIG fibronectin type III domain + plectin-1
    • 6gvl - hIG fibronectin type III domain + dystonin
    • 6gvk - hIG fibronectin type III domain (mutant) + dystonin
    • 3fq4, 3fso, 3h6a – hIG Calx-β domain
    • 6hyf - rIG fibronectin type III domain
  • IG β-7
    • 2brq, 2jf1 – hIG cytoplasmic tail + filamin rod domain

}}

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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