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Intercellular adhesion molecule

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Current revision (09:35, 5 October 2021) (edit) (undo)
 
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<StructureSection load='1mq8' size='340' side='right' caption='Structure of glycosylated human ICAM-1 domains 1-2 (grey and pink) complex with LFA-1 (yellow and green) and Mg+2 ion (green) (PDB code [[1mq8]]).' scene=''>
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<StructureSection load='1mq8' size='340' side='right' caption='Structure of glycosylated human ICAM-1 domains 1-2 (grey) complex with LFA-1 (green) and Mg+2 ion (green) (PDB code [[1mq8]]).' scene=''>
== Function ==
== Function ==
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'''Intercellular adhesion molecule''' (ICAM) is part of the immunoglobulin superfamily. ICAM binds to LFA-1 and macrophage-1 antigen during inflammation. ICAM contains 5 Ig-like domains.
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'''Intercellular adhesion molecule''' (ICAM) is part of the immunoglobulin superfamily. ICAM binds to leukocyte function associated molecule 1 (LFA-1) and macrophage-1 antigen during inflammation<ref>PMID:8834767</ref>. ICAM contains 5 Ig-like domains.
== Disease ==
== Disease ==
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ICAM mutation is involved in multiple sclerosis<ref>PMID:12590979</ref>.
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== Relevance ==
 
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== Structural highlights ==
 
</StructureSection>
</StructureSection>
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**[[1d3e]], [[1d3i]] – hICAM N terminal domain + rhinovirus coat proteins - CryoEM<br />
**[[1d3e]], [[1d3i]] – hICAM N terminal domain + rhinovirus coat proteins - CryoEM<br />
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**[[7bg7]] – hICAM + rhinovirus polyproteins - CryoEM<br />
**[[1mq8]] – hICAM domain 1-2 + LFA-1<br />
**[[1mq8]] – hICAM domain 1-2 + LFA-1<br />
**[[3tcx]] – hICAM domain 1 + LFA-1<br />
**[[3tcx]] – hICAM domain 1 + LFA-1<br />
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**[[6eit]] – hICAM domain 1-2 + coxsakievirus coat proteins - CryoEM<br />
**[[1z7z]] – hICAM domain 1-5 + coxsakievirus coat proteins - CryoEM<br />
**[[1z7z]] – hICAM domain 1-5 + coxsakievirus coat proteins - CryoEM<br />
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**[[2qz4]] – hICAM domain 4 + antibody<br />
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**[[2oz4]] – hICAM domain 4 + antibody<br />
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**[[5mza]], [[6s8u]] – hICAM residues 28-212 + erythrocyte membrane protein 1<br />
*ICAM-2
*ICAM-2

Current revision

Structure of glycosylated human ICAM-1 domains 1-2 (grey) complex with LFA-1 (green) and Mg+2 ion (green) (PDB code 1mq8).

Drag the structure with the mouse to rotate

3D structures of intercellular adhesion molecule

Updated on 05-October-2021

References

  1. ↑ van de Stolpe A, van der Saag PT. Intercellular adhesion molecule-1. J Mol Med (Berl). 1996 Jan;74(1):13-33. PMID:8834767
  2. ↑ Nejentsev S, Laaksonen M, Tienari PJ, Fernandez O, Cordell H, Ruutiainen J, Wikstrom J, Pastinen T, Kuokkanen S, Hillert J, Ilonen J. Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis. Hum Immunol. 2003 Mar;64(3):345-9. PMID:12590979

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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