1fbn

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[[Image:1fbn.gif|left|200px]]
[[Image:1fbn.gif|left|200px]]
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{{Structure
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|PDB= 1fbn |SIZE=350|CAPTION= <scene name='initialview01'>1fbn</scene>, resolution 1.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1fbn", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK04266 PRK04266]</span>
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{{STRUCTURE_1fbn| PDB=1fbn | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fbn OCA], [http://www.ebi.ac.uk/pdbsum/1fbn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fbn RCSB]</span>
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'''CRYSTAL STRUCTURE OF A FIBRILLARIN HOMOLOGUE FROM METHANOCOCCUS JANNASCHII, A HYPERTHERMOPHILE, AT 1.6 A'''
'''CRYSTAL STRUCTURE OF A FIBRILLARIN HOMOLOGUE FROM METHANOCOCCUS JANNASCHII, A HYPERTHERMOPHILE, AT 1.6 A'''
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[[Category: Kim, S H.]]
[[Category: Kim, S H.]]
[[Category: Wang, H.]]
[[Category: Wang, H.]]
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[[Category: berkeley structural genomics center]]
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[[Category: Berkeley structural genomics center]]
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[[Category: bsgc structure funded by nih]]
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[[Category: Bsgc structure funded by nih]]
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[[Category: fibrillarin]]
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[[Category: Fibrillarin]]
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[[Category: mj protein]]
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[[Category: Mj protein]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: psi]]
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[[Category: Psi]]
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[[Category: ribosomal rna processing]]
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[[Category: Ribosomal rna processing]]
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[[Category: snornp]]
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[[Category: Snornp]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:08:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:19:45 2008''
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Revision as of 13:08, 2 May 2008

Image:1fbn.gif

Template:STRUCTURE 1fbn

CRYSTAL STRUCTURE OF A FIBRILLARIN HOMOLOGUE FROM METHANOCOCCUS JANNASCHII, A HYPERTHERMOPHILE, AT 1.6 A


Overview

Fibrillarin is a phylogenetically conserved protein essential for efficient processing of pre-rRNA through its association with a class of small nucleolar RNAs during ribosomal biogenesis. The protein is the antigen for the autoimmune disease scleroderma. Here we report the crystal structure of the fibrillarin homologue from Methanococcus jannaschii, a hyperthermophile, at 1.6 A resolution. The structure consists of two domains, with a novel fold in the N-terminal region and a methyltransferase-like domain in the C-terminal region. Mapping temperature-sensitive mutations found in yeast fibrillarin Nop1 to the Methanococcus homologue structure reveals that many of the mutations cluster in the core of the methyltransferase-like domain.

About this Structure

1FBN is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

Crystal structure of a fibrillarin homologue from Methanococcus jannaschii, a hyperthermophile, at 1.6 A resolution., Wang H, Boisvert D, Kim KK, Kim R, Kim SH, EMBO J. 2000 Feb 1;19(3):317-23. PMID:10654930 Page seeded by OCA on Fri May 2 16:08:18 2008

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