1ug3

<StructureSection load='1ug3' size='340' side='right'caption='[[1ug3]], [[Resolution|resolution]] 2.24&Aring;' scene=''>

<table><tr><td colspan='2'>[[1ug3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UG3 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ug3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ug3 OCA], [http://pdbe.org/1ug3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ug3 RCSB], [http://www.ebi.ac.uk/pdbsum/1ug3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ug3 ProSAT]</span></td></tr>

== Disease ==

[[http://www.uniprot.org/uniprot/IF4G1_HUMAN IF4G1_HUMAN]] Defects in EIF4G1 are the cause of Parkinson disease type 18 (PARK18) [MIM:[http://omim.org/entry/614251 614251]]. An autosomal dominant, late-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.<ref>PMID:21907011</ref>

== Function ==

[[http://www.uniprot.org/uniprot/IF4G1_HUMAN IF4G1_HUMAN]] Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.

*[[C-terminal portion of human eIF4GI|C-terminal portion of human eIF4GI]]

*[[Death Associated Protein 5|Death Associated Protein 5]]

== References ==

<references/>

[[Category: Human]]

[[Category: Bellsolell, L]]

[[Category: Burley, S K]]

[[Category: Cho-Park, P F]]

[[Category: Poulin, F]]

[[Category: Sonenberg, N]]

[[Category: Translation]]