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1wwl

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<StructureSection load='1wwl' size='340' side='right'caption='[[1wwl]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='1wwl' size='340' side='right'caption='[[1wwl]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1wwl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WWL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1wwl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WWL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wwl OCA], [http://pdbe.org/1wwl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wwl RCSB], [http://www.ebi.ac.uk/pdbsum/1wwl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wwl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wwl OCA], [https://pdbe.org/1wwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wwl RCSB], [https://www.ebi.ac.uk/pdbsum/1wwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wwl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD14_MOUSE CD14_MOUSE]] Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules (By similarity).
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[[https://www.uniprot.org/uniprot/CD14_MOUSE CD14_MOUSE]] Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 06:30, 6 October 2021

Crystal structure of CD14

PDB ID 1wwl

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