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3hwn

From Proteopedia

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[[Image:3hwn.png|left|200px]]
 
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{{STRUCTURE_3hwn| PDB=3hwn | SCENE= }}
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==CATHEPSIN L with AZ13010160==
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<StructureSection load='3hwn' size='340' side='right'caption='[[3hwn]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3hwn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HWN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BD3:NALPHA-[(3-TERT-BUTYL-1-METHYL-1H-PYRAZOL-5-YL)CARBONYL]-N-[(2E)-2-IMINOETHYL]-3-{5-[(Z)-IMINOMETHYL]-1,3,4-OXADIAZOL-2-YL}-L-PHENYLALANINAMIDE'>BD3</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSL1, CTSL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hwn OCA], [https://pdbe.org/3hwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hwn RCSB], [https://www.ebi.ac.uk/pdbsum/3hwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hwn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN]] Important for the overall degradation of proteins in lysosomes.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hw/3hwn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hwn ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A number of molecular recognition features have been exploited in structure-based design of selective Cathepsin inhibitors.
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===CATHEPSIN L with AZ13010160===
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Design of selective Cathepsin inhibitors.,Bethel PA, Gerhardt S, Jones EV, Kenny PW, Karoutchi GI, Morley AD, Oldham K, Rankine N, Augustin M, Krapp S, Simader H, Steinbacher S Bioorg Med Chem Lett. 2009 Aug 15;19(16):4622-5. Epub 2009 Jun 27. PMID:19616430<ref>PMID:19616430</ref>
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{{ABSTRACT_PUBMED_19616430}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3hwn" style="background-color:#fffaf0;"></div>
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[[3hwn]] is a 4 chain structure of [[Cathepsin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HWN OCA].
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==See Also==
==See Also==
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*[[Cathepsin|Cathepsin]]
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019616430</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Cathepsin L]]
[[Category: Cathepsin L]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Kenny, P.]]
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[[Category: Large Structures]]
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[[Category: Morley, A.]]
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[[Category: Kenny, P]]
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[[Category: Morley, A]]
[[Category: Cathepsin l]]
[[Category: Cathepsin l]]
[[Category: Disulfide bond]]
[[Category: Disulfide bond]]

Current revision

CATHEPSIN L with AZ13010160

PDB ID 3hwn

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