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3hy7
From Proteopedia
(Difference between revisions)
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==Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with Marimastat== | ==Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with Marimastat== | ||
| - | <StructureSection load='3hy7' size='340' side='right' caption='[[3hy7]], [[Resolution|resolution]] 1.69Å' scene=''> | + | <StructureSection load='3hy7' size='340' side='right'caption='[[3hy7]], [[Resolution|resolution]] 1.69Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3hy7]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3hy7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HY7 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=097:(2S,3R)-N~4~-[(1S)-2,2-DIMETHYL-1-(METHYLCARBAMOYL)PROPYL]-N~1~,2-DIHYDROXY-3-(2-METHYLPROPYL)BUTANEDIAMIDE'>097</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=097:(2S,3R)-N~4~-[(1S)-2,2-DIMETHYL-1-(METHYLCARBAMOYL)PROPYL]-N~1~,2-DIHYDROXY-3-(2-METHYLPROPYL)BUTANEDIAMIDE'>097</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3b8z|3b8z]], [[3hy9|3hy9]], [[3hyg|3hyg]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3b8z|3b8z]], [[3hy9|3hy9]], [[3hyg|3hyg]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADAMTS-5, ADAMTS11, ADAMTS5, ADMP2 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADAMTS-5, ADAMTS11, ADAMTS5, ADMP2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hy7 OCA], [https://pdbe.org/3hy7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hy7 RCSB], [https://www.ebi.ac.uk/pdbsum/3hy7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hy7 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ATS5_HUMAN ATS5_HUMAN]] Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/3hy7_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/3hy7_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</div> | </div> | ||
<div class="pdbe-citations 3hy7" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3hy7" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[A Disintegrin And Metalloproteinase 3D structures|A Disintegrin And Metalloproteinase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Caspers, N]] | [[Category: Caspers, N]] | ||
[[Category: Mathis, K J]] | [[Category: Mathis, K J]] | ||
Revision as of 12:05, 13 October 2021
Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with Marimastat
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Categories: Human | Large Structures | Caspers, N | Mathis, K J | Shieh, H S | Tomasselli, A | Tortorella, M D | Williams, J M | Alpha/beta structure | Central five stranded beta-sheet | Cleavage on pair of basic residue | Disulfide bond | Extracellular matrix | Glycoprotein | Hydrolase | Metal-binding | Metalloprotease | Polymorphism | Protease | Secreted | Zinc | Zymogen
