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3kdf

From Proteopedia

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{{Seed}}
 
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[[Image:3kdf.png|left|200px]]
 
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==X-ray Crystal Structure of the Human Replication Protein A Complex from Wheat Germ Cell Free Expression==
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The line below this paragraph, containing "STRUCTURE_3kdf", creates the "Structure Box" on the page.
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<StructureSection load='3kdf' size='340' side='right'caption='[[3kdf]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kdf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KDF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KDF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3kdf| PDB=3kdf | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">REPA3, RPA14, RPA3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), REPA2, RPA2, RPA32, RPA34 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kdf OCA], [https://pdbe.org/3kdf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kdf RCSB], [https://www.ebi.ac.uk/pdbsum/3kdf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kdf ProSAT]</span></td></tr>
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===X-ray Crystal Structure of the Human Replication Protein A Complex from Wheat Germ Cell Free Expression===
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/RFA3_HUMAN RFA3_HUMAN]] Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> [[https://www.uniprot.org/uniprot/RFA2_HUMAN RFA2_HUMAN]] Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage.<ref>PMID:15205463</ref> <ref>PMID:19116208</ref> <ref>PMID:19996105</ref> <ref>PMID:20154705</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:15205463</ref> <ref>PMID:19116208</ref> <ref>PMID:19996105</ref> <ref>PMID:20154705</ref>
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==About this Structure==
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== Evolutionary Conservation ==
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3KDF is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KDF OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Homo sapiens]]
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Check<jmol>
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[[Category: Bingman, C A.]]
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<jmolCheckbox>
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[[Category: Burgie, E S.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kd/3kdf_consurf.spt"</scriptWhenChecked>
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[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Jr., G N.Phillips.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kdf ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Bingman, C A]]
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[[Category: Burgie, E S]]
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[[Category: Structural genomic]]
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[[Category: Fox, B G]]
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[[Category: Makino, S I]]
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[[Category: Phillips, G N]]
[[Category: Acetylation]]
[[Category: Acetylation]]
[[Category: Alternative splicing]]
[[Category: Alternative splicing]]
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[[Category: Center for eukaryotic structural genomic]]
 
[[Category: Cesg]]
[[Category: Cesg]]
[[Category: Dna replication]]
[[Category: Dna replication]]
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[[Category: Polymorphism]]
[[Category: Polymorphism]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Protein structure initiative]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Replication]]
[[Category: Replication protein some]]
[[Category: Replication protein some]]
[[Category: Wheat germ cell free]]
[[Category: Wheat germ cell free]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:37:16 2010''
 

Current revision

X-ray Crystal Structure of the Human Replication Protein A Complex from Wheat Germ Cell Free Expression

PDB ID 3kdf

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