1few

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[[Image:1few.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1few FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1few OCA], [http://www.ebi.ac.uk/pdbsum/1few PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1few RCSB]</span>
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'''CRYSTAL STRUCTURE OF SMAC/DIABLO'''
'''CRYSTAL STRUCTURE OF SMAC/DIABLO'''
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[[Category: Chai, J.]]
[[Category: Chai, J.]]
[[Category: Shi, Y.]]
[[Category: Shi, Y.]]
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[[Category: apoptosis]]
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[[Category: Apoptosis]]
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[[Category: caspase activation]]
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[[Category: Caspase activation]]
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[[Category: diablo]]
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[[Category: Diablo]]
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[[Category: iap inhibition]]
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[[Category: Iap inhibition]]
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[[Category: smac]]
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[[Category: Smac]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:21:29 2008''
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Revision as of 13:14, 2 May 2008

Image:1few.gif

Template:STRUCTURE 1few

CRYSTAL STRUCTURE OF SMAC/DIABLO


Overview

Apoptosis (programmed cell death), an essential process in the development and homeostasis of metazoans, is carried out by caspases. The mitochondrial protein Smac/DIABLO performs a critical function in apoptosis by eliminating the inhibitory effect of IAPs (inhibitor of apoptosis proteins) on caspases. Here we show that Smac/DIABLO promotes not only the proteolytic activation of procaspase-3 but also the enzymatic activity of mature caspase-3, both of which depend upon its ability to interact physically with IAPs. The crystal structure of Smac/DIABLO at 2.2 A resolution reveals that it homodimerizes through an extensive hydrophobic interface. Missense mutations inactivating this dimeric interface significantly compromise the function of Smac/DIABLO. As in the Drosophila proteins Reaper, Grim and Hid, the amino-terminal amino acids of Smac/DIABLO are indispensable for its function, and a seven-residue peptide derived from the amino terminus promotes procaspase-3 activation in vitro. These results establish an evolutionarily conserved structural and biochemical basis for the activation of apoptosis by Smac/DIABLO.

About this Structure

1FEW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural and biochemical basis of apoptotic activation by Smac/DIABLO., Chai J, Du C, Wu JW, Kyin S, Wang X, Shi Y, Nature. 2000 Aug 24;406(6798):855-62. PMID:10972280 Page seeded by OCA on Fri May 2 16:14:35 2008

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