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3lmk
From Proteopedia
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| - | [[Image:3lmk.png|left|200px]] | ||
| - | + | ==Ligand Binding Domain of Metabotropoc glutamate receptor mGluR5 complexed with glutamate== | |
| - | + | <StructureSection load='3lmk' size='340' side='right'caption='[[3lmk]], [[Resolution|resolution]] 2.44Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3lmk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LMK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | == | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GPRC1E, GRM5, MGLUR5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | [[3lmk]] is a 2 chain structure with sequence from [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lmk OCA], [https://pdbe.org/3lmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lmk RCSB], [https://www.ebi.ac.uk/pdbsum/3lmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lmk ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/GRM5_HUMAN GRM5_HUMAN]] Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lm/3lmk_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lmk ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | + | *[[Metabotropic glutamate receptor 3D structures|Metabotropic glutamate receptor 3D structures]] | |
| - | *[[Metabotropic glutamate receptor|Metabotropic glutamate receptor]] | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Arrowsmith, C H | + | [[Category: Human]] |
| - | [[Category: Bochkarev, A | + | [[Category: Large Structures]] |
| - | [[Category: Bountra, C | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Cossar, D | + | [[Category: Bochkarev, A]] |
| - | [[Category: Dobrovetsky, E | + | [[Category: Bountra, C]] |
| - | [[Category: Edwards, A M | + | [[Category: Cossar, D]] |
| - | [[Category: Khutoreskaya, G | + | [[Category: Dobrovetsky, E]] |
| - | [[Category: | + | [[Category: Edwards, A M]] |
| - | [[Category: Seitova, A | + | [[Category: Khutoreskaya, G]] |
| - | [[Category: Weigelt, J | + | [[Category: Structural genomic]] |
| + | [[Category: Seitova, A]] | ||
| + | [[Category: Weigelt, J]] | ||
[[Category: Cell membrane]] | [[Category: Cell membrane]] | ||
[[Category: Dimerization]] | [[Category: Dimerization]] | ||
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[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: Structural genomics consortium]] | ||
[[Category: Transducer]] | [[Category: Transducer]] | ||
[[Category: Transmembrane]] | [[Category: Transmembrane]] | ||
Current revision
Ligand Binding Domain of Metabotropoc glutamate receptor mGluR5 complexed with glutamate
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Categories: Human | Large Structures | Arrowsmith, C H | Bochkarev, A | Bountra, C | Cossar, D | Dobrovetsky, E | Edwards, A M | Khutoreskaya, G | Structural genomic | Seitova, A | Weigelt, J | Cell membrane | Dimerization | G-protein coupled receptor | Glutamate receptor | Glutamic acid | Glycoprotein | Membrane | Mglur1 | Receptor | Sgc | Signaling protein | Transducer | Transmembrane
