1vok

<StructureSection load='1vok' size='340' side='right'caption='[[1vok]], [[Resolution|resolution]] 2.10&Aring;' scene=''>

<table><tr><td colspan='2'>[[1vok]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VOK FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vok OCA], [http://pdbe.org/1vok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vok RCSB], [http://www.ebi.ac.uk/pdbsum/1vok PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vok ProSAT]</span></td></tr>

== Function ==

[[http://www.uniprot.org/uniprot/TBP1_ARATH TBP1_ARATH]] General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.

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== Publication Abstract from PubMed ==

The three-dimensional structure of a TATA box-binding protein (TBP2) from Arabidopsis thaliana has been refined at 2.1 A resolution. TBPs are general eukaryotic transcription factors that participate in initiation of RNA synthesis by all three eukaryotic RNA polymerases. The carboxy-terminal portion of TBP is a unique DNA-binding motif/protein fold, adopting a highly symmetric alpha/beta structure that resembles a molecular saddle with two stirrup-like loops. A ten-stranded, antiparallel beta-sheet provides a concave surface for recognizing class II nuclear gene promoters, while the four amphipathic alpha-helices on the convex surface are available for interaction with other transcription factors. The myriad interactions of TBP2 with components of the transcription machinery are discussed.

2.1 A resolution refined structure of a TATA box-binding protein (TBP).,Nikolov DB, Burley SK Nat Struct Biol. 1994 Sep;1(9):621-37. PMID:7634102<ref>PMID:7634102</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1vok" style="background-color:#fffaf0;"></div>

*[[TATA-Binding Protein|TATA-Binding Protein]]

[[Category: Arath]]

[[Category: Burley, S K]]

[[Category: Nikolov, D B]]

[[Category: Transcription initiation]]