3g8l

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{{Seed}}
 
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[[Image:3g8l.jpg|left|200px]]
 
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==Crystal structure of murine natural killer cell receptor, Ly49L4==
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The line below this paragraph, containing "STRUCTURE_3g8l", creates the "Structure Box" on the page.
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<StructureSection load='3g8l' size='340' side='right'caption='[[3g8l]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3g8l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G8L FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3g8k|3g8k]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Klra12, MOUSE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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{{STRUCTURE_3g8l| PDB=3g8l | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8l OCA], [https://pdbe.org/3g8l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g8l RCSB], [https://www.ebi.ac.uk/pdbsum/3g8l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g8l ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/3g8l_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g8l ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Certain cell-surface receptors engage ligands expressed on juxtaposed cells and ligands on the same cell. The structural basis for trans versus cis binding is not known. Here, we showed that Ly49 natural killer (NK) cell receptors bound two MHC class I (MHC-I) molecules in trans when the two ligand-binding domains were backfolded onto the long stalk region. In contrast, dissociation of the ligand-binding domains from the stalk and their reorientation relative to the NK cell membrane allowed monovalent binding of MHC-I in cis. The distinct conformations (backfolded and extended) define the structural basis for cis-trans binding by Ly49 receptors and explain the divergent functional consequences of cis versus trans interactions. Further analyses identified specific stalk segments that were not required for MHC-I binding in trans but were essential for inhibitory receptor function. These data identify multiple distinct roles of stalk regions for receptor function.
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===Crystal structure of murine natural killer cell receptor, Ly49L4===
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Distinct conformations of Ly49 natural killer cell receptors mediate MHC class I recognition in trans and cis.,Back J, Malchiodi EL, Cho S, Scarpellino L, Schneider P, Kerzic MC, Mariuzza RA, Held W Immunity. 2009 Oct 16;31(4):598-608. Epub 2009 Oct 8. PMID:19818651<ref>PMID:19818651</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3g8l" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19818651}}, adds the Publication Abstract to the page
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*[[NK cell receptor|NK cell receptor]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19818651 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19818651}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3G8L is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8L OCA].
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[[Category: Lk3 transgenic mice]]
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[[Category: Cho, S]]
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==Reference==
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<ref group="xtra">PMID:19818651</ref><references group="xtra"/>
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[[Category: Mus musculus]]
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[[Category: Cho, S.]]
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[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Ly49]]
[[Category: Ly49]]
[[Category: Natural killer cell receptor]]
[[Category: Natural killer cell receptor]]
[[Category: Receptor]]
[[Category: Receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 19:29:45 2009''
 

Current revision

Crystal structure of murine natural killer cell receptor, Ly49L4

PDB ID 3g8l

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