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2lyz
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="2lyz" size="450" color="white" frame="true" align="right" spinBox="true" caption="2lyz, resolution 2.0Å" /> '''REAL-SPACE REFINEMEN...) |
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| - | [[Image:2lyz.gif|left|200px]]<br /> | ||
| - | <applet load="2lyz" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2lyz, resolution 2.0Å" /> | ||
| - | '''REAL-SPACE REFINEMENT OF THE STRUCTURE OF HEN EGG-WHITE LYSOZYME'''<br /> | ||
| - | == | + | ==Real-space refinement of the structure of hen egg-white lysozyme== |
| - | + | <StructureSection load='2lyz' size='340' side='right'caption='[[2lyz]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2lyz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. The September 2000 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Lysozyme'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2000_9 10.2210/rcsb_pdb/mom_2000_9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LYZ FirstGlance]. <br> | ||
| + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lyz OCA], [https://pdbe.org/2lyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lyz RCSB], [https://www.ebi.ac.uk/pdbsum/2lyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lyz ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ly/2lyz_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2lyz ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Lysozyme 3D structures|Lysozyme 3D structures]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Gallus gallus]] | [[Category: Gallus gallus]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Lysozyme]] | [[Category: Lysozyme]] | ||
| - | [[Category: | + | [[Category: RCSB PDB Molecule of the Month]] |
| - | [[Category: Blake, C | + | [[Category: Blake, C C.F]] |
| - | [[Category: Diamond, R | + | [[Category: Diamond, R]] |
| - | [[Category: North, A | + | [[Category: North, A C.T]] |
| - | [[Category: Phillips, D | + | [[Category: Phillips, D C]] |
| - | [[Category: | + | [[Category: Hydrolase]] |
| - | + | ||
| - | + | ||
Current revision
Real-space refinement of the structure of hen egg-white lysozyme
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