1fjl

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[[Image:1fjl.gif|left|200px]]
[[Image:1fjl.gif|left|200px]]
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{{Structure
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|PDB= 1fjl |SIZE=350|CAPTION= <scene name='initialview01'>1fjl</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1fjl", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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|GENE=
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{{STRUCTURE_1fjl| PDB=1fjl | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fjl OCA], [http://www.ebi.ac.uk/pdbsum/1fjl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fjl RCSB]</span>
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'''HOMEODOMAIN FROM THE DROSOPHILA PAIRED PROTEIN BOUND TO A DNA OLIGONUCLEOTIDE'''
'''HOMEODOMAIN FROM THE DROSOPHILA PAIRED PROTEIN BOUND TO A DNA OLIGONUCLEOTIDE'''
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[[Category: Kuriyan, J.]]
[[Category: Kuriyan, J.]]
[[Category: Wilson, D S.]]
[[Category: Wilson, D S.]]
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[[Category: dna]]
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[[Category: Dna]]
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[[Category: dna-binding protein]]
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[[Category: Dna-binding protein]]
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[[Category: paired box]]
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[[Category: Paired box]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:24:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:24:10 2008''
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Revision as of 13:24, 2 May 2008

Image:1fjl.gif

Template:STRUCTURE 1fjl

HOMEODOMAIN FROM THE DROSOPHILA PAIRED PROTEIN BOUND TO A DNA OLIGONUCLEOTIDE


Overview

The crystal structure of the paired homeodomain bound to DNA as a cooperative dimer has been determined to 2.0 A resolution. Direct contacts between each homeodomain and the DNA are similar to those described previously. In addition, an extensive network of water molecules mediates contacts between the recognition helix and the DNA major groove. Several symmetrical contacts between the two homeodomains underlie the cooperative interaction, and deformations in the DNA structure are necessary for the establishment of these contacts. Comparison with structures of homeodomains bound monomerically to DNA suggests that the binding of a single paired homeodomain can introduce these DNA distortions, thus preparing a template for the cooperative interaction with a second homeodomain. This study shows how the paired (Pax) class homeodomains have achieved cooperativity in DNA binding without the assistance of other domains, thereby enabling the recognition of target sequences that are long enough to ensure specificity.

About this Structure

1FJL is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

High resolution crystal structure of a paired (Pax) class cooperative homeodomain dimer on DNA., Wilson DS, Guenther B, Desplan C, Kuriyan J, Cell. 1995 Sep 8;82(5):709-19. PMID:7671301 Page seeded by OCA on Fri May 2 16:24:16 2008

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