This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3jsv
From Proteopedia
(Difference between revisions)
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==Crystal structure of mouse NEMO CoZi in complex with Lys63-linked di-ubiquitin== | ==Crystal structure of mouse NEMO CoZi in complex with Lys63-linked di-ubiquitin== | ||
| - | <StructureSection load='3jsv' size='340' side='right' caption='[[3jsv]], [[Resolution|resolution]] 2.70Å' scene=''> | + | <StructureSection load='3jsv' size='340' side='right'caption='[[3jsv]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3jsv]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3jsv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JSV FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3f89|3f89]], [[2zvo|2zvo]], [[2zvn|2zvn]], [[3fx0|3fx0]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3f89|3f89]], [[2zvo|2zvo]], [[2zvn|2zvn]], [[3fx0|3fx0]]</div></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ikbkg, Nemo, NEMO(249-343) ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ikbkg, Nemo, NEMO(249-343) ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsv OCA], [https://pdbe.org/3jsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jsv RCSB], [https://www.ebi.ac.uk/pdbsum/3jsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsv ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/NEMO_MOUSE NEMO_MOUSE]] Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (By similarity).<ref>PMID:9927690</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsv_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsv_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jsv ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
| Line 25: | Line 28: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3jsv" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[3D structures of ubiquitin|3D structures of ubiquitin]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Fukai, S | + | [[Category: Lk3 transgenic mice]] |
| - | [[Category: Mimura, H | + | [[Category: Fukai, S]] |
| - | [[Category: Sato, Y | + | [[Category: Mimura, H]] |
| - | [[Category: Yamagata, A | + | [[Category: Sato, Y]] |
| - | [[Category: Yamashita, M | + | [[Category: Yamagata, A]] |
| - | [[Category: Yoshikawa, A | + | [[Category: Yamashita, M]] |
| + | [[Category: Yoshikawa, A]] | ||
[[Category: Cellular signaling]] | [[Category: Cellular signaling]] | ||
| + | [[Category: Coiled coil]] | ||
[[Category: Coiled-coil]] | [[Category: Coiled-coil]] | ||
| + | [[Category: Cytoplasm]] | ||
[[Category: Disulfide bond]] | [[Category: Disulfide bond]] | ||
[[Category: Isopeptide bond]] | [[Category: Isopeptide bond]] | ||
| Line 51: | Line 58: | ||
[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
[[Category: Ubiquitin]] | [[Category: Ubiquitin]] | ||
| + | [[Category: Ubl conjugation]] | ||
| + | [[Category: Zinc]] | ||
[[Category: Zinc-finger]] | [[Category: Zinc-finger]] | ||
Current revision
Crystal structure of mouse NEMO CoZi in complex with Lys63-linked di-ubiquitin
| |||||||||||
Categories: Human | Large Structures | Lk3 transgenic mice | Fukai, S | Mimura, H | Sato, Y | Yamagata, A | Yamashita, M | Yoshikawa, A | Cellular signaling | Coiled coil | Coiled-coil | Cytoplasm | Disulfide bond | Isopeptide bond | Metal-binding | Nucleus | Phosphoprotein | Signaling protein-transcription complex | Transcription | Transcription regulation | Ubiquitin | Ubl conjugation | Zinc | Zinc-finger
