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2x47
From Proteopedia
(Difference between revisions)
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<StructureSection load='2x47' size='340' side='right'caption='[[2x47]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='2x47' size='340' side='right'caption='[[2x47]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2x47]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2x47]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X47 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x47 OCA], [https://pdbe.org/2x47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x47 RCSB], [https://www.ebi.ac.uk/pdbsum/2x47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x47 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/MACD1_HUMAN MACD1_HUMAN]] A chromosomal aberration involving MACROD1 is found in acute leukemia. Translocation t(11;21)(q13;q22) that forms a RUNX1-MACROD1 fusion protein. |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/MACD1_HUMAN MACD1_HUMAN]] Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.<ref>PMID:17893710</ref> <ref>PMID:17914104</ref> <ref>PMID:19022849</ref> <ref>PMID:19403568</ref> <ref>PMID:23474712</ref> <ref>PMID:21257746</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 08:35, 10 November 2021
Crystal structure of human MACROD1
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