GABAA receptor
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<StructureSection load='5o8f' size='340' side='right' caption='Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with pregnanolone (based on [[5o8f]]) scene='89/896619/Cv/3'> | <StructureSection load='5o8f' size='340' side='right' caption='Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with pregnanolone (based on [[5o8f]]) scene='89/896619/Cv/3'> | ||
| - | '''GABAA receptors''', which is considered ligand-gated ion channels as the binding of GABA results in the opening of ion channels leading to the inhibition of a neuronal signal. Excitatory neurosteroids have excitatory effects on neurotransmission. They act as potent negative allosteric modulators of the GABAA receptor. Major examples include the pregnanes pregnenolone sulfate (PS), epipregnanolone, and isopregnanolone (sepranolone). *<scene name='89/896619/Cv/5'>Pregnenolone alone</scene>. | + | '''GABAA receptors''', which is considered ligand-gated ion channels as the binding of GABA results in the opening of ion channels leading to the inhibition of a neuronal signal. Excitatory neurosteroids have excitatory effects on neurotransmission. They act as potent negative allosteric modulators of the GABAA receptor. Major examples include the pregnanes pregnenolone sulfate (PS), epipregnanolone, and isopregnanolone (sepranolone). |
| + | *<scene name='89/896619/Cv/5'>Pregnenolone alone</scene>. | ||
*<scene name='89/896619/Cv/4'>Pregnanolone binds beta3-alpha5 GABAA receptor</scene> ([[5o8f]]). | *<scene name='89/896619/Cv/4'>Pregnanolone binds beta3-alpha5 GABAA receptor</scene> ([[5o8f]]). | ||
*<scene name='89/896619/Cv/6'>Pregnanolone binding site is situated between 2 monomers</scene>. | *<scene name='89/896619/Cv/6'>Pregnanolone binding site is situated between 2 monomers</scene>. | ||
Revision as of 11:41, 16 November 2021
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