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Nerve growth factor
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref...) |
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| - | + | <StructureSection load='1www' size='340' side='right' caption='Human NGF (green, yellowgreen) complex with TrkA receptor domain 5 (cyan, deepskyblue) (PDB code [[1www]])' scene='84/845929/Cv/1'> | |
| - | <StructureSection load=' | + | |
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== Function == | == Function == | ||
| - | + | '''Nerve growth factor''' (NGF) belongs to the family of neurotrophins. NGF promotes survival and differentiation of sensory and sympathetic neurons. NGF signaling furthers neuroprotective and repair functions<ref>PMID:11520933</ref>. NGF interacts with 2 transmembrane receptors - TrkA and p75. | |
== Relevance == | == Relevance == | ||
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| + | Increased cerebrospinal fluid levels of proNGF mark the onset of mild cognitive impairment and the transition to Alzheimer disease suggest that NGF is a potential Alzheimer biomarker<ref>PMID:31312116</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
| + | The 3D structure of the complex between human NGF and one of its receptors - TrkA - shows the <scene name='84/845929/Cv/4'>receptor D-5 domain Ig-like structure</scene> flanking the <scene name='84/845929/Cv/5'>NGF homodimer</scene>. Various side chains form the <scene name='84/845929/Cv/10'>interactions between NGF and its receptor</scene> with a <scene name='84/845929/Cv/11'>totally buried NGF Arg residue forming the strongest one</scene><ref>PMID:10490030</ref>. Water molecules are shown as red spheres. | ||
</StructureSection> | </StructureSection> | ||
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==3D structures of nerve growth factor== | ==3D structures of nerve growth factor== | ||
| - | [[4edk]], [[4edw]], [[5jz7]] - hβ-NGF + antibody | + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} |
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| + | [[6yw8]] - hβ-NGF – human - NMR<br /> | ||
| + | [[4edk]], [[4edw]], [[5jz7]] - hβ-NGF + antibody<br /> | ||
[[2ifg]], [[1www]] - hβ-NGF + TrkA<br /> | [[2ifg]], [[1www]] - hβ-NGF + TrkA<br /> | ||
[[1sg1]] - hβ-NGF + neutrophin receptor<br /> | [[1sg1]] - hβ-NGF + neutrophin receptor<br /> | ||
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[[6xuo]] - NGF - horse<br /> | [[6xuo]] - NGF - horse<br /> | ||
[[1btg]], [[5lsd]], [[1sgf]], [[1bet]] - mNGF - mouse<br /> | [[1btg]], [[5lsd]], [[1sgf]], [[1bet]] - mNGF - mouse<br /> | ||
| - | [[4xpj]] - mNGF + | + | [[4xpj]], [[4eax]] - mNGF + lipid<br /> |
| - | [[4ec7]] - NGF - cobra<br /> | + | [[6ffy]] - mNGF + SorCS2<br /> |
| + | [[3ij2]] - mNGF + TNFR<br /> | ||
| + | [[4ec7]] - NGF + lipid - cobra<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
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3D structures of nerve growth factor
Updated on 17-November-2021
6yw8 - hβ-NGF – human - NMR
4edk, 4edw, 5jz7 - hβ-NGF + antibody
2ifg, 1www - hβ-NGF + TrkA
1sg1 - hβ-NGF + neutrophin receptor
4zbn - hβ-NGF + DNA
6xuo - NGF - horse
1btg, 5lsd, 1sgf, 1bet - mNGF - mouse
4xpj, 4eax - mNGF + lipid
6ffy - mNGF + SorCS2
3ij2 - mNGF + TNFR
4ec7 - NGF + lipid - cobra
References
- ↑ Sofroniew MV, Howe CL, Mobley WC. Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci. 2001;24:1217-81. doi: 10.1146/annurev.neuro.24.1.1217. PMID:11520933 doi:http://dx.doi.org/10.1146/annurev.neuro.24.1.1217
- ↑ Mufson EJ, Counts SE, Ginsberg SD, Mahady L, Perez SE, Massa SM, Longo FM, Ikonomovic MD. Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease. Front Neurosci. 2019 Jul 1;13:533. doi: 10.3389/fnins.2019.00533. eCollection, 2019. PMID:31312116 doi:http://dx.doi.org/10.3389/fnins.2019.00533
- ↑ Wiesmann C, Ultsch MH, Bass SH, de Vos AM. Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. Nature. 1999 Sep 9;401(6749):184-8. PMID:10490030 doi:10.1038/43705
