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1fq1

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[[Image:1fq1.jpg|left|200px]]
[[Image:1fq1.jpg|left|200px]]
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{{Structure
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|PDB= 1fq1 |SIZE=350|CAPTION= <scene name='initialview01'>1fq1</scene>, resolution 3.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1fq1", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
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{{STRUCTURE_1fq1| PDB=1fq1 | SCENE= }}
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|RELATEDENTRY=[[1fpz|1FPZ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fq1 OCA], [http://www.ebi.ac.uk/pdbsum/1fq1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fq1 RCSB]</span>
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'''CRYSTAL STRUCTURE OF KINASE ASSOCIATED PHOSPHATASE (KAP) IN COMPLEX WITH PHOSPHO-CDK2'''
'''CRYSTAL STRUCTURE OF KINASE ASSOCIATED PHOSPHATASE (KAP) IN COMPLEX WITH PHOSPHO-CDK2'''
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[[Category: Noble, M E.M.]]
[[Category: Noble, M E.M.]]
[[Category: Song, H.]]
[[Category: Song, H.]]
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[[Category: phospho-protein/protein complex]]
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[[Category: Phospho-protein/protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:37:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:28:02 2008''
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Revision as of 13:37, 2 May 2008

Image:1fq1.jpg

Template:STRUCTURE 1fq1

CRYSTAL STRUCTURE OF KINASE ASSOCIATED PHOSPHATASE (KAP) IN COMPLEX WITH PHOSPHO-CDK2


Overview

The CDK-interacting protein phosphatase KAP dephosphorylates phosphoThr-160 (pThr-160) of the CDK2 activation segment, the site of regulatory phosphorylation that is essential for kinase activity. Here we describe the crystal structure of KAP in association with pThr-160-CDK2, representing an example of a protein phosphatase in complex with its intact protein substrate. The major protein interface between the two molecules is formed by the C-terminal lobe of CDK2 and the C-terminal helix of KAP, regions remote from the kinase-activation segment and the KAP catalytic site. The kinase-activation segment interacts with the catalytic site of KAP almost entirely via the phosphate group of pThr-160. This interaction requires that the activation segment is unfolded and drawn away from the kinase molecule, inducing a conformation of CDK2 similar to the activated state observed in the CDK2/cyclin A complex.

About this Structure

1FQ1 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2., Song H, Hanlon N, Brown NR, Noble ME, Johnson LN, Barford D, Mol Cell. 2001 Mar;7(3):615-26. PMID:11463386 Page seeded by OCA on Fri May 2 16:37:50 2008

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