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7pn1
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7pn1 is ON HOLD Authors: Killer, M., Wald, J., Pieprzyk, J., Marlovits, T.C., Loew, C. Description: Apo HsPepT1 in the outward facing open conforma...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Apo HsPepT1 in the outward facing open conformation== | |
| + | <StructureSection load='7pn1' size='340' side='right'caption='[[7pn1]], [[Resolution|resolution]] 3.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7pn1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PN1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pn1 OCA], [https://pdbe.org/7pn1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pn1 RCSB], [https://www.ebi.ac.uk/pdbsum/7pn1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pn1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/S15A1_HUMAN S15A1_HUMAN]] Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:7896779, PubMed:18367661, PubMed:19685173). Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (By similarity).[UniProtKB:P36836]<ref>PMID:18367661</ref> <ref>PMID:19685173</ref> <ref>PMID:7896779</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | [Figure: see text]. | ||
| - | + | Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.,Killer M, Wald J, Pieprzyk J, Marlovits TC, Low C Sci Adv. 2021 Nov 5;7(45):eabk3259. doi: 10.1126/sciadv.abk3259. Epub 2021 Nov 3. PMID:34730990<ref>PMID:34730990</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 7pn1" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Killer, M]] | ||
[[Category: Loew, C]] | [[Category: Loew, C]] | ||
| + | [[Category: Marlovits, T C]] | ||
[[Category: Pieprzyk, J]] | [[Category: Pieprzyk, J]] | ||
| - | [[Category: Killer, M]] | ||
| - | [[Category: Marlovits, T.C]] | ||
[[Category: Wald, J]] | [[Category: Wald, J]] | ||
| + | [[Category: Hspept1]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Pept1]] | ||
| + | [[Category: Peptide transporter]] | ||
Current revision
Apo HsPepT1 in the outward facing open conformation
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