This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2uwq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:50, 17 November 2021) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2uwq.jpg|left|200px]]
 
-
{{Structure
+
==Solution structure of ASPP2 N-terminus==
-
|PDB= 2uwq |SIZE=350|CAPTION= <scene name='initialview01'>2uwq</scene>
+
<StructureSection load='2uwq' size='340' side='right'caption='[[2uwq]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[2uwq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UWQ FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ycs|1ycs]]</div></td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwq OCA], [https://pdbe.org/2uwq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uwq RCSB], [https://www.ebi.ac.uk/pdbsum/2uwq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwq ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=
+
== Evolutionary Conservation ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwq OCA], [http://www.ebi.ac.uk/pdbsum/2uwq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2uwq RCSB]</span>
+
[[Image:Consurf_key_small.gif|200px|right]]
-
}}
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
'''SOLUTION STRUCTURE OF ASPP2 N-TERMINUS'''
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/2uwq_consurf.spt"</scriptWhenChecked>
-
 
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==Overview==
+
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uwq ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
Proteins of the ASPP family bind to p53 and regulate p53-mediated apoptosis. Two family members, ASPP1 and ASPP2, have pro-apoptotic functions while iASPP shows anti-apoptotic responses. However, both the mechanism of enhancement/repression of apoptosis and the molecular basis for their different responses remain unknown. To address the role of the N-termini of pro-apoptotic ASPP proteins, we solved the solution structure of N-ASPP2 (1-83) by NMR spectroscopy. The structure of this domain reveals a beta-Grasp ubiquitin-like fold. Our findings suggest a possible role for the N-termini of ASPP proteins in binding to other proteins in the apoptotic response network and thus mediating their selective pro-apoptotic function.
Proteins of the ASPP family bind to p53 and regulate p53-mediated apoptosis. Two family members, ASPP1 and ASPP2, have pro-apoptotic functions while iASPP shows anti-apoptotic responses. However, both the mechanism of enhancement/repression of apoptosis and the molecular basis for their different responses remain unknown. To address the role of the N-termini of pro-apoptotic ASPP proteins, we solved the solution structure of N-ASPP2 (1-83) by NMR spectroscopy. The structure of this domain reveals a beta-Grasp ubiquitin-like fold. Our findings suggest a possible role for the N-termini of ASPP proteins in binding to other proteins in the apoptotic response network and thus mediating their selective pro-apoptotic function.
-
==About this Structure==
+
Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold.,Tidow H, Andreeva A, Rutherford TJ, Fersht AR J Mol Biol. 2007 Aug 24;371(4):948-58. Epub 2007 May 13. PMID:17594908<ref>PMID:17594908</ref>
-
2UWQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWQ OCA].
+
-
 
+
-
==Reference==
+
-
Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold., Tidow H, Andreeva A, Rutherford TJ, Fersht AR, J Mol Biol. 2007 Aug 24;371(4):948-58. Epub 2007 May 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17594908 17594908]
+
-
[[Category: Homo sapiens]]
+
-
[[Category: Single protein]]
+
-
[[Category: Andreeva, A.]]
+
-
[[Category: Fersht, A R.]]
+
-
[[Category: Rutherford, T J.]]
+
-
[[Category: Tidow, H.]]
+
-
[[Category: ank repeat]]
+
-
[[Category: apoptosis]]
+
-
[[Category: aspp2]]
+
-
[[Category: cell cycle]]
+
-
[[Category: sh3-binding]]
+
-
[[Category: sh3-domain]]
+
-
[[Category: ubiquitin-like]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:05:34 2008''
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2uwq" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Human]]
 +
[[Category: Large Structures]]
 +
[[Category: Andreeva, A]]
 +
[[Category: Fersht, A R]]
 +
[[Category: Rutherford, T J]]
 +
[[Category: Tidow, H]]
 +
[[Category: Ank repeat]]
 +
[[Category: Apoptosis]]
 +
[[Category: Aspp2]]
 +
[[Category: Cell cycle]]
 +
[[Category: Sh3-binding]]
 +
[[Category: Sh3-domain]]
 +
[[Category: Ubiquitin-like]]

Current revision

Solution structure of ASPP2 N-terminus

PDB ID 2uwq

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2uwq"
Personal tools