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NK cell receptor

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Line 33: Line 33:
**[[3bdw]], [[3cii]] – hNKG2D extracellular domain + CD94 + MHC class I antigen E + β-2-microglobulin + HLA G antigen<br />
**[[3bdw]], [[3cii]] – hNKG2D extracellular domain + CD94 + MHC class I antigen E + β-2-microglobulin + HLA G antigen<br />
-
*NKP
+
*NKp
-
**[[1hkf]] – hNKP44 IG domain <br />
+
**[[6yjp]] – hNKp30 IG domain 19-130 + hNKp30 ligand<br />
-
**[[1oll]], [[1p6f]] – hNKP46 extracellular domain <br />
+
**[[1hkf]] – hNKp44 IG domain <br />
 +
**[[1oll]], [[1p6f]] – hNKp46 extracellular domain 25-212<br />
*2B4
*2B4
Line 52: Line 53:
*'''Inhibitory NK cell receptors'''
*'''Inhibitory NK cell receptors'''
-
*KIR
+
*KIR or killer cell immunoglobulin-like receptor
**[[3wyr]] – hKIR2dl4 extracellular domain <br />
**[[3wyr]] – hKIR2dl4 extracellular domain <br />
**[[3h8n]] – hKIR2ds4 extracellular domain <br />
**[[3h8n]] – hKIR2ds4 extracellular domain <br />
-
**[[3wuw]], [[5t70]], [[5t6z]], [[5b39]], [[5b38]], [[3vh8]] – hKIR3dl1
+
**[[3wuw]], [[5t70]], [[5t6z]], [[5b39]], [[5b38]], [[3vh8]], [[6v3j]], [[7k80]] – hKIR3dl1
extracellular domain + MHC class I antigen B + β-2-microglobulin + IG κ chain C region<br />
extracellular domain + MHC class I antigen B + β-2-microglobulin + IG κ chain C region<br />
 +
**[[6pag]] – hKIR3dl3 extracellular domain + MHC class I antigen B + β-2-microglobulin + peptide<br />
 +
**[[6pa1]] – hKIR2dl2 extracellular domain + MHC class I antigen B + β-2-microglobulin + peptide<br />
**[[4n8v]] – hKIR2ds2 extracellular domain + MHC class I antigen B + β-2-microglobulin + peptide<br />
**[[4n8v]] – hKIR2ds2 extracellular domain + MHC class I antigen B + β-2-microglobulin + peptide<br />
 +
 +
*KLRG1
 +
 +
**[[3fft]] – hKLRG1 + cadherin<br />
}}
}}

Revision as of 08:28, 24 November 2021

Human NK cell receptor NKG2D (grey and green) complex with class I MHC-like ligand ULBP3 (pink) and glutathione (PDB entry 1kcg)

Drag the structure with the mouse to rotate

3D structures of NK cell receptor

Updated on 24-November-2021

extracellular domain + MHC class I antigen B + β-2-microglobulin + IG κ chain C region

References

  1. ↑ Lanier LL. NK cell receptors. Annu Rev Immunol. 1998;16:359-93. PMID:9597134 doi:http://dx.doi.org/10.1146/annurev.immunol.16.1.359
  2. ↑ Mathew SO, Rao KK, Kim JR, Bambard ND, Mathew PA. Functional role of human NK cell receptor 2B4 (CD244) isoforms. Eur J Immunol. 2009 Jun;39(6):1632-41. doi: 10.1002/eji.200838733. PMID:19499526 doi:http://dx.doi.org/10.1002/eji.200838733
  3. ↑ Kane KP, Lavender KJ, Ma BJ. Ly-49 receptors and their functions. Crit Rev Immunol. 2004;24(5):321-48. PMID:15663362
  4. ↑ Norman PJ, Carrington CV, Byng M, Maxwell LD, Curran MD, Stephens HA, Chandanayingyong D, Verity DH, Hameed K, Ramdath DD, Vaughan RW. Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations. Genes Immun. 2002 Apr;3(2):86-95. PMID:11960306 doi:http://dx.doi.org/10.1038/sj.gene.6363836
  5. ↑ Raulet DH. Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol. 2003 Oct;3(10):781-90. PMID:14523385 doi:http://dx.doi.org/10.1038/nri1199

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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