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2yrj

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==Solution structure of the C2H2-type zinc finger domain (781-813) from zinc finger protein 473==
==Solution structure of the C2H2-type zinc finger domain (781-813) from zinc finger protein 473==
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<StructureSection load='2yrj' size='340' side='right' caption='[[2yrj]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2yrj' size='340' side='right'caption='[[2yrj]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2yrj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YRJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YRJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2yrj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YRJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yrh|2yrh]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yrh|2yrh]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZNF473 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZNF473 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yrj OCA], [http://pdbe.org/2yrj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yrj RCSB], [http://www.ebi.ac.uk/pdbsum/2yrj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yrj ProSAT], [http://www.topsan.org/Proteins/RSGI/2yrj TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yrj OCA], [https://pdbe.org/2yrj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yrj RCSB], [https://www.ebi.ac.uk/pdbsum/2yrj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yrj ProSAT], [https://www.topsan.org/Proteins/RSGI/2yrj TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ZN473_HUMAN ZN473_HUMAN]] Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.<ref>PMID:11782445</ref> <ref>PMID:16914750</ref> <ref>PMID:16714279</ref>
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[[https://www.uniprot.org/uniprot/ZN473_HUMAN ZN473_HUMAN]] Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.<ref>PMID:11782445</ref> <ref>PMID:16914750</ref> <ref>PMID:16714279</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Hayashi, F]]
[[Category: Hayashi, F]]
[[Category: Izumi, K]]
[[Category: Izumi, K]]

Revision as of 13:36, 24 November 2021

Solution structure of the C2H2-type zinc finger domain (781-813) from zinc finger protein 473

PDB ID 2yrj

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