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7rsq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of KIFBP core== | |
| + | <StructureSection load='7rsq' size='340' side='right'caption='[[7rsq]], [[Resolution|resolution]] 3.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7rsq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RSQ FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIFBP, KBP, KIAA1279, KIF1BP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rsq OCA], [https://pdbe.org/7rsq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rsq RCSB], [https://www.ebi.ac.uk/pdbsum/7rsq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rsq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/KBP_HUMAN KBP_HUMAN]] Goldberg-Shprintzen megacolon syndrome. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/KBP_HUMAN KBP_HUMAN]] Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.<ref>PMID:16225668</ref> <ref>PMID:20621975</ref> <ref>PMID:23427148</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | [Figure: see text]. | ||
| - | + | Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding.,Solon AL, Tan Z, Schutt KL, Jepsen L, Haynes SE, Nesvizhskii AI, Sept D, Stumpff J, Ohi R, Cianfrocco MA Sci Adv. 2021 Nov 19;7(47):eabj9812. doi: 10.1126/sciadv.abj9812. Epub 2021 Nov, 19. PMID:34797717<ref>PMID:34797717</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 7rsq" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Haynes, S | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cianfrocco, M A]] | ||
| + | [[Category: Haynes, S E]] | ||
[[Category: Jepsen, L]] | [[Category: Jepsen, L]] | ||
| - | + | [[Category: Nesvizhskii, A I]] | |
| - | [[Category: Nesvizhskii, A | + | |
[[Category: Ohi, R]] | [[Category: Ohi, R]] | ||
| + | [[Category: Schutt, K L]] | ||
| + | [[Category: Sept, D]] | ||
| + | [[Category: Solon, A L]] | ||
| + | [[Category: Stumpff, J]] | ||
[[Category: Tan, Z]] | [[Category: Tan, Z]] | ||
| - | [[Category: | + | [[Category: Kinesin regulation protein]] |
| + | [[Category: Motor protein]] | ||
Current revision
Cryo-EM structure of KIFBP core
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