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2kl7
From Proteopedia
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| - | [[Image:2kl7.png|left|200px]] | ||
| - | + | ==Solution NMR Structure of the EGF-like 1 Domain of Human Fibulin-4. Northeast Structural Genomics Target HR6275== | |
| - | + | <StructureSection load='2kl7' size='340' side='right'caption='[[2kl7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2kl7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KL7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EFEMP2, FBLN4, UNQ200/PRO226 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kl7 OCA], [https://pdbe.org/2kl7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kl7 RCSB], [https://www.ebi.ac.uk/pdbsum/2kl7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kl7 ProSAT], [https://www.topsan.org/Proteins/NESGC/2kl7 TOPSAN]</span></td></tr> |
| - | [[2kl7]] is a 1 chain structure with sequence from [ | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: Anderson, S | + | [[https://www.uniprot.org/uniprot/FBLN4_HUMAN FBLN4_HUMAN]] Autosomal recessive cutis laxa type 1;Lethal arteriopathy syndrome due to Fibulin-4 deficiency. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:16685658</ref> <ref>PMID:17937443</ref> <ref>PMID:19664000</ref> |
| - | [[Category: Chiang, Y | + | == Evolutionary Conservation == |
| - | [[Category: Montelione, G T | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[Category: | + | Check<jmol> |
| - | [[Category: Rossi, P | + | <jmolCheckbox> |
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/2kl7_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kl7 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Anderson, S]] | ||
| + | [[Category: Chiang, Y]] | ||
| + | [[Category: Montelione, G T]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Rossi, P]] | ||
| + | [[Category: Calcium]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
[[Category: Disulfide bond]] | [[Category: Disulfide bond]] | ||
| Line 20: | Line 37: | ||
[[Category: Metal binding protein]] | [[Category: Metal binding protein]] | ||
[[Category: Nesg]] | [[Category: Nesg]] | ||
| - | [[Category: | + | [[Category: Polymorphism]] |
| - | [[Category: Protein structure initiative | + | [[Category: PSI, Protein structure initiative]] |
| - | + | ||
[[Category: Secreted]] | [[Category: Secreted]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Structural protein]] | [[Category: Structural protein]] | ||
Current revision
Solution NMR Structure of the EGF-like 1 Domain of Human Fibulin-4. Northeast Structural Genomics Target HR6275
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Categories: Human | Large Structures | Anderson, S | Chiang, Y | Montelione, G T | Structural genomic | Rossi, P | Calcium | Disease mutation | Disulfide bond | Egf-like domain | Glycoprotein | Metal binding protein | Nesg | Polymorphism | PSI, Protein structure initiative | Secreted | Signaling protein | Structural protein
