This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2kl7
From Proteopedia
(Difference between revisions)
| (8 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
| - | [[Image:2kl7.jpg|left|200px]] | ||
| - | + | ==Solution NMR Structure of the EGF-like 1 Domain of Human Fibulin-4. Northeast Structural Genomics Target HR6275== | |
| - | + | <StructureSection load='2kl7' size='340' side='right'caption='[[2kl7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2kl7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KL7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EFEMP2, FBLN4, UNQ200/PRO226 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kl7 OCA], [https://pdbe.org/2kl7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kl7 RCSB], [https://www.ebi.ac.uk/pdbsum/2kl7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kl7 ProSAT], [https://www.topsan.org/Proteins/NESGC/2kl7 TOPSAN]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Disease == | |
| - | + | [[https://www.uniprot.org/uniprot/FBLN4_HUMAN FBLN4_HUMAN]] Autosomal recessive cutis laxa type 1;Lethal arteriopathy syndrome due to Fibulin-4 deficiency. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:16685658</ref> <ref>PMID:17937443</ref> <ref>PMID:19664000</ref> | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | == | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | [[Category: | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/2kl7_consurf.spt"</scriptWhenChecked> |
| - | [[Category: Anderson, S | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [[Category: Chiang, Y | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [[Category: Montelione, G T | + | </jmolCheckbox> |
| - | [[Category: | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kl7 ConSurf]. |
| - | [[Category: Rossi, P | + | <div style="clear:both"></div> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Anderson, S]] | ||
| + | [[Category: Chiang, Y]] | ||
| + | [[Category: Montelione, G T]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Rossi, P]] | ||
[[Category: Calcium]] | [[Category: Calcium]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
| Line 28: | Line 37: | ||
[[Category: Metal binding protein]] | [[Category: Metal binding protein]] | ||
[[Category: Nesg]] | [[Category: Nesg]] | ||
| - | [[Category: Northeast structural genomics consortium]] | ||
[[Category: Polymorphism]] | [[Category: Polymorphism]] | ||
| - | [[Category: Protein structure initiative | + | [[Category: PSI, Protein structure initiative]] |
| - | + | ||
[[Category: Secreted]] | [[Category: Secreted]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Structural protein]] | [[Category: Structural protein]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 22 20:29:29 2009'' | ||
Current revision
Solution NMR Structure of the EGF-like 1 Domain of Human Fibulin-4. Northeast Structural Genomics Target HR6275
| |||||||||||
Categories: Human | Large Structures | Anderson, S | Chiang, Y | Montelione, G T | Structural genomic | Rossi, P | Calcium | Disease mutation | Disulfide bond | Egf-like domain | Glycoprotein | Metal binding protein | Nesg | Polymorphism | PSI, Protein structure initiative | Secreted | Signaling protein | Structural protein
