7s5t
From Proteopedia
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(New page: '''Unreleased structure''' The entry 7s5t is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Human KATP channel in open conformation, focused on Kir (C166S G334D double mutant) and SUR TMD0== | |
| + | <StructureSection load='7s5t' size='340' side='right'caption='[[7s5t]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7s5t]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S5T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S5T FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s5t OCA], [https://pdbe.org/7s5t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s5t RCSB], [https://www.ebi.ac.uk/pdbsum/7s5t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s5t ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | KATP channels are metabolic sensors that translate intracellular ATP/ADP balance into membrane excitability. The molecular composition of KATP includes an inward-rectifier potassium channel (Kir) and an ABC transporter-like sulfonylurea receptor (SUR). Although structures of KATP have been determined in many conformations, in all cases, the pore in Kir is closed. Here, we describe human pancreatic KATP (hKATP) structures with an open pore at 3.1- to 4.0-A resolution using single-particle cryo-electron microscopy (cryo-EM). Pore opening is associated with coordinated structural changes within the ATP-binding site and the channel gate in Kir. Conformational changes in SUR are also observed, resulting in an area reduction of contact surfaces between SUR and Kir. We also observe that pancreatic hKATP exhibits the unique (among inward-rectifier channels) property of PIP2-independent opening, which appears to be correlated with a docked cytoplasmic domain in the absence of PIP2. | ||
| - | + | Molecular structure of an open human KATP channel.,Zhao C, MacKinnon R Proc Natl Acad Sci U S A. 2021 Nov 30;118(48). pii: 2112267118. doi:, 10.1073/pnas.2112267118. PMID:34815345<ref>PMID:34815345</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 7s5t" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: MacKinnon, R]] | ||
| + | [[Category: Zhao, C]] | ||
| + | [[Category: Atp-sensitive potassium channel]] | ||
| + | [[Category: Ion channel]] | ||
| + | [[Category: Katp]] | ||
| + | [[Category: Membrane protein]] | ||
Current revision
Human KATP channel in open conformation, focused on Kir (C166S G334D double mutant) and SUR TMD0
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