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2d4z

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Revision as of 10:27, 8 December 2021

Crystal structure of the cytoplasmic domain of the chloride channel ClC-0

Structural highlights

2d4z is a 2 chain structure with sequence from Marbled electric ray. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CICH_TORMA] Voltage-gated chloride channel. This channel is thought to ensure the high conductance of the non-innervated membrane of the electrocyte necessary for efficient current generation caused by sodium influx through the acetylcholine receptor at the innervated membrane.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Ion channels are frequently organized in a modular fashion and consist of a membrane-embedded pore domain and a soluble regulatory domain. A similar organization is found for the ClC family of Cl- channels and transporters. Here, we describe the crystal structure of the cytoplasmic domain of ClC-0, the voltage-dependent Cl- channel from T. marmorata. The structure contains a folded core of two tightly interacting cystathionine beta-synthetase (CBS) subdomains. The two subdomains are connected by a 96 residue mobile linker that is disordered in the crystals. As revealed by analytical ultracentrifugation, the domains form dimers, thereby most likely extending the 2-fold symmetry of the transmembrane pore. The structure provides insight into the organization of the cytoplasmic domains within the ClC family and establishes a framework for guiding future investigations on regulatory mechanisms.

Crystal structure of the cytoplasmic domain of the chloride channel ClC-0.,Meyer S, Dutzler R Structure. 2006 Feb;14(2):299-307. PMID:16472749^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Meyer S, Dutzler R. Crystal structure of the cytoplasmic domain of the chloride channel ClC-0. Structure. 2006 Feb;14(2):299-307. PMID:16472749 doi:10.1016/j.str.2005.10.008

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2d4z"

@@ Line 3: / Line 3: @@
 <StructureSection load='2d4z' size='340' side='right'caption='[[2d4z]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2d4z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Marbled_electric_ray Marbled electric ray]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2D4Z FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2d4z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Marbled_electric_ray Marbled electric ray]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D4Z FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d4z OCA], [http://pdbe.org/2d4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2d4z RCSB], [http://www.ebi.ac.uk/pdbsum/2d4z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2d4z ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d4z OCA], [https://pdbe.org/2d4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d4z RCSB], [https://www.ebi.ac.uk/pdbsum/2d4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d4z ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CICH_TORMA CICH_TORMA]] Voltage-gated chloride channel. This channel is thought to ensure the high conductance of the non-innervated membrane of the electrocyte necessary for efficient current generation caused by sodium influx through the acetylcholine receptor at the innervated membrane.
+[[https://www.uniprot.org/uniprot/CICH_TORMA CICH_TORMA]] Voltage-gated chloride channel. This channel is thought to ensure the high conductance of the non-innervated membrane of the electrocyte necessary for efficient current generation caused by sodium influx through the acetylcholine receptor at the innervated membrane.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

2d4z

From Proteopedia

Revision as of 10:27, 8 December 2021

Crystal structure of the cytoplasmic domain of the chloride channel ClC-0

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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