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2yxd

From Proteopedia

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[[Image:2yxd.gif|left|200px]]
 
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{{Structure
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==Crystal Structure of Cobalamin biosynthesis precorrin 8W decarboxylase (cbiT)==
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|PDB= 2yxd |SIZE=350|CAPTION= <scene name='initialview01'>2yxd</scene>, resolution 2.30&Aring;
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<StructureSection load='2yxd' size='340' side='right'caption='[[2yxd]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC ACID'>MES</scene>
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<table><tr><td colspan='2'>[[2yxd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Metja Metja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YXD FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|GENE= cbiT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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}}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cbiT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243232 METJA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxd OCA], [https://pdbe.org/2yxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yxd RCSB], [https://www.ebi.ac.uk/pdbsum/2yxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yxd ProSAT], [https://www.topsan.org/Proteins/RSGI/2yxd TOPSAN]</span></td></tr>
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'''Crystal Structure of Cobalamin biosynthesis precorrin 8W decarboxylase (cbiT)'''
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/CBIT_METJA CBIT_METJA]] Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7 (By similarity).
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==About this Structure==
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== Evolutionary Conservation ==
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2YXD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXD OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Methanocaldococcus jannaschii]]
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Check<jmol>
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[[Category: Single protein]]
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<jmolCheckbox>
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[[Category: Bessho, Y.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yx/2yxd_consurf.spt"</scriptWhenChecked>
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[[Category: Padmanabhan, B.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Yokoyama, S.]]
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</jmolCheckbox>
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[[Category: MES]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yxd ConSurf].
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[[Category: SO4]]
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<div style="clear:both"></div>
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[[Category: alpha and beta protein (a/b) class]]
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__TOC__
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[[Category: methyltransferase superfamily]]
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</StructureSection>
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[[Category: national project on protein structural and functional analyse]]
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[[Category: Large Structures]]
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[[Category: nppsfa]]
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[[Category: Metja]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: Bessho, Y]]
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[[Category: rsgi]]
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[[Category: Padmanabhan, B]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: Yokoyama, S]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:50:03 2008''
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[[Category: Methyltransferase superfamily]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Transferase]]

Current revision

Crystal Structure of Cobalamin biosynthesis precorrin 8W decarboxylase (cbiT)

PDB ID 2yxd

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