Ca2+ signalling processes
From Proteopedia
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<StructureSection load='1n4K' size='350' side='right' caption='Mouse inositol triphosphate receptor ligand-binding core complex with its ligand inositol triphosphate (PDB entry [[1n4k]])' scene='38/382942/Cv/1'> | <StructureSection load='1n4K' size='350' side='right' caption='Mouse inositol triphosphate receptor ligand-binding core complex with its ligand inositol triphosphate (PDB entry [[1n4k]])' scene='38/382942/Cv/1'> | ||
*[[Inositol 1,4,5-Trisphosphate Receptor]] | *[[Inositol 1,4,5-Trisphosphate Receptor]] | ||
| - | [[Inositol 1,4,5-Trisphosphate Receptor]] binding protein is a ubiquitous protein involved in the Ca<sup>2+</sup> signalling processes in a variety of organisms <ref name="mainpaper">PMID:12442173</ref> | + | [[Inositol 1,4,5-Trisphosphate Receptor]] binding protein is a ubiquitous protein involved in the Ca<sup>2+</sup> signalling processes in a variety of organisms <ref name="mainpaper">PMID:12442173</ref>. The specific type of inositol 1,4,5-trisphosphate receptor (InsP<sub>3</sub>R) protein discussed here is the mouse type 1 InsP<sub>3</sub>R, also called InsP<sub>3</sub>R1. This polypeptide contains three major regions: the <scene name='38/382942/N_terminal_domain/1'>amino terminal</scene> inositol 1,4,5-trisphosphate (InsP<sub>3</sub>) binding region, the central modulatory region, and the <scene name='38/382942/C_terminal_domain/1'>carboxy-terminus channel region</scene>.<ref name="mainpaper"/> The protein forms an L-shaped structure composed of two asymmetric domains perpendicular to each other.<ref name="mainpaper"/> The N-terminal domain is made up of 12 β-strands and 2 single-turn helices, which come together to form a barrel.<ref name="mainpaper"/> The C-terminal end is quite different, consisting of a bundle made of eight α-helices.<ref name="mainpaper"/> The interface of the two domains is lined with basic residues and forms the <scene name='38/382942/Ip3_binding_pocket/1'>receptor site</scene> for InsP<sub>3</sub>.<ref name="mainpaper"/> The InsP<sub>3</sub>R protein does not belong to a superfamily of proteins. The receptor is thought to span the membrane 6 times, leaving the C-terminus in the cytoplasm.<ref name="functionref"/> |
*[[Calcium-dependent protein kinase]] | *[[Calcium-dependent protein kinase]] | ||
*[[Calcium/Calmodulin-dependent protein kinase]] | *[[Calcium/Calmodulin-dependent protein kinase]] | ||
Revision as of 14:51, 13 December 2021
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References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Bosanac I, Alattia JR, Mal TK, Chan J, Talarico S, Tong FK, Tong KI, Yoshikawa F, Furuichi T, Iwai M, Michikawa T, Mikoshiba K, Ikura M. Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand. Nature. 2002 Dec 12;420(6916):696-700. Epub 2002 Nov 17. PMID:12442173 doi:10.1038/nature01268
- ↑ Cite error: Invalid
<ref>tag; no text was provided for refs namedfunctionref
