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7axu
From Proteopedia
(Difference between revisions)
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==Structure of WDR5:CS-VIP8 cocrystal after illumination in situ== | ==Structure of WDR5:CS-VIP8 cocrystal after illumination in situ== | ||
| - | <StructureSection load='7axu' size='340' side='right'caption='[[7axu]]' scene=''> | + | <StructureSection load='7axu' size='340' side='right'caption='[[7axu]], [[Resolution|resolution]] 1.68Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AXU FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7axu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AXU FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7axu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7axu OCA], [https://pdbe.org/7axu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7axu RCSB], [https://www.ebi.ac.uk/pdbsum/7axu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7axu ProSAT]</span></td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7axs|7axs]], [[7axq|7axq]], [[7axp|7axp]]</div></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7axu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7axu OCA], [https://pdbe.org/7axu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7axu RCSB], [https://www.ebi.ac.uk/pdbsum/7axu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7axu ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Essen L | + | [[Category: Essen, L O]] |
| - | [[Category: Werel L]] | + | [[Category: Werel, L]] |
| + | [[Category: Cyclic strained visible-light photoswitch]] | ||
| + | [[Category: Inhibition of hematopoiesis]] | ||
| + | [[Category: Mll1 complex disruption]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Wdr5]] | ||
Revision as of 16:54, 15 December 2021
Structure of WDR5:CS-VIP8 cocrystal after illumination in situ
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