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2dx0
From Proteopedia
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| - | [[Image:2dx0.jpg|left|200px]]<br /><applet load="2dx0" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2dx0, resolution 2.50Å" /> | ||
| - | '''Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2'''<br /> | ||
| - | == | + | ==Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2== |
| - | + | <StructureSection load='2dx0' size='340' side='right'caption='[[2dx0]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [ | + | <table><tr><td colspan='2'>[[2dx0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DX0 FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dx0 OCA], [https://pdbe.org/2dx0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dx0 RCSB], [https://www.ebi.ac.uk/pdbsum/2dx0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dx0 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dx0 TOPSAN]</span></td></tr> | |
| - | [ | + | </table> |
| - | [ | + | == Function == |
| - | [[ | + | [[https://www.uniprot.org/uniprot/PLCG2_MOUSE PLCG2_MOUSE]] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity). |
| - | + | == Evolutionary Conservation == | |
| - | [[ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/2dx0_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | [ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [[ | + | </jmolCheckbox> |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dx0 ConSurf]. | |
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Phospholipase C|Phospholipase C]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lk3 transgenic mice]] | ||
| + | [[Category: Handa, N]] | ||
| + | [[Category: Murayama, K]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Shirouzu, M]] | ||
| + | [[Category: Takagi, T]] | ||
| + | [[Category: Terada, T]] | ||
| + | [[Category: Yokoyama, S]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: National project on protein structural and functional analyse]] | ||
| + | [[Category: Nppsfa]] | ||
| + | [[Category: Phosphoric diester hydrolase]] | ||
| + | [[Category: Rsgi]] | ||
Current revision
Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2
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