This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2edj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (17:23, 15 December 2021) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2edj.jpg|left|200px]]
 
-
<!--
+
==Solution structure of the fifth ig-like domain from human Roundabout homolog 2==
-
The line below this paragraph, containing "STRUCTURE_2edj", creates the "Structure Box" on the page.
+
<StructureSection load='2edj' size='340' side='right'caption='[[2edj]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2edj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EDJ FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2edj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edj OCA], [https://pdbe.org/2edj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2edj RCSB], [https://www.ebi.ac.uk/pdbsum/2edj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2edj ProSAT], [https://www.topsan.org/Proteins/RSGI/2edj TOPSAN]</span></td></tr>
-
-->
+
</table>
-
{{STRUCTURE_2edj| PDB=2edj | SCENE= }}
+
== Disease ==
-
 
+
[[https://www.uniprot.org/uniprot/ROBO2_HUMAN ROBO2_HUMAN]] Defects in ROBO2 are the cause of vesicoureteral reflux type 2 (VUR2) [MIM:[https://omim.org/entry/610878 610878]]. VUR is a complex, genetically heterogeneous developmental disorder characterized by the retrograde flow of urine from the bladder into the ureter and is associated with reflux nephropathy, the cause of 15% of end-stage renal disease in children and young adults.<ref>PMID:17357069</ref> Note=A chromosomal aberration involving ROBO2 is a cause of multiple congenital abnormalities, including severe bilateral VUR with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with PCDH11Y. This translocation disrupts ROBO2 and produces dominant-negative ROBO2 proteins that abrogate SLIT-ROBO signaling in vitro.
-
'''Solution structure of the fifth ig-like domain from human Roundabout homolog 2'''
+
== Function ==
-
 
+
[[https://www.uniprot.org/uniprot/ROBO2_HUMAN ROBO2_HUMAN]] Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.
-
 
+
== Evolutionary Conservation ==
-
==About this Structure==
+
[[Image:Consurf_key_small.gif|200px|right]]
-
2EDJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDJ OCA].
+
Check<jmol>
-
[[Category: Homo sapiens]]
+
<jmolCheckbox>
-
[[Category: Single protein]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/2edj_consurf.spt"</scriptWhenChecked>
-
[[Category: Hayashi, F.]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[Category: Izumi, K.]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: Kurosaki, C.]]
+
</jmolCheckbox>
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2edj ConSurf].
-
[[Category: Yokoyama, S.]]
+
<div style="clear:both"></div>
-
[[Category: Yoshida, M.]]
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Human]]
 +
[[Category: Large Structures]]
 +
[[Category: Hayashi, F]]
 +
[[Category: Izumi, K]]
 +
[[Category: Kurosaki, C]]
 +
[[Category: Structural genomic]]
 +
[[Category: Yokoyama, S]]
 +
[[Category: Yoshida, M]]
[[Category: Beta sandwich]]
[[Category: Beta sandwich]]
[[Category: Cell adhesion]]
[[Category: Cell adhesion]]
Line 27: Line 37:
[[Category: National project on protein structural and functional analyse]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Nppsfa]]
-
[[Category: Riken structural genomics/proteomics initiative]]
 
[[Category: Rsgi]]
[[Category: Rsgi]]
-
[[Category: Structural genomic]]
 
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 02:22:38 2008''
 

Current revision

Solution structure of the fifth ig-like domain from human Roundabout homolog 2

PDB ID 2edj

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2edj"
Personal tools