Journal:Acta Cryst F:S2053230X21013455
From Proteopedia
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<b>Molecular Tour</b><br> | <b>Molecular Tour</b><br> | ||
| - | ''Burkholderia pseudomallei'' is a rod-shaped, motile, flagellated, soil-dwelling gram-negative proteobacterium of the Burkholderiaceae family that thrives in tropical and subtropical regions. ''B. pseudomallei'' causes melioidosis, a deadly emerging opportunistic infection mainly of the immunocompromised. ''B. pseudomallei'' is transmitted through open wounds, contact with contaminated soil and water, ingestion, or inhalation, and is also a potential biological warfare agent. The Seattle Structural Genomics Center for Infectious Disease (SSGCID) has determined and solved X-ray structures of a potential drug target betaine aldehyde dehydrogenase (BADH) from ''B. pseudomallei'' (''Bp''BADH) | + | ''Burkholderia pseudomallei'' is a rod-shaped, motile, flagellated, soil-dwelling gram-negative proteobacterium of the Burkholderiaceae family that thrives in tropical and subtropical regions. ''B. pseudomallei'' causes melioidosis, a deadly emerging opportunistic infection mainly of the immunocompromised. ''B. pseudomallei'' is transmitted through open wounds, contact with contaminated soil and water, ingestion, or inhalation, and is also a potential biological warfare agent. The Seattle Structural Genomics Center for Infectious Disease (SSGCID) has determined and solved X-ray structures of a potential drug target betaine aldehyde dehydrogenase (BADH) from ''B. pseudomallei'' (''Bp''BADH): |
| - | *<scene name='89/899476/Cv/2'>Monomer of apo BpBADH</scene> | + | *<scene name='89/899476/Cv/2'>Monomer of apo BpBADH</scene>, colored in rainbow from blue (N-terminus) to (red) C-terminus; [[6wsa]]. |
| + | *<scene name='89/899476/Cv/3'>Dimer of BpBADH with NAD</scene>, monomers are shown as green and cyan ribbons, with NAD shown as ball-and-sticks. | ||
The structures are similar to those of BADH from ''Pseudomonas aeruginosa'' (''Pa''BADH). ''Pa''BADH is inhibited by the drug disulfiram which is an approved drug. Our preliminary analysis could facilitate drug repurposing studies for melioidosis. This project is an educational collaboration between the SSGCID and Hampton University. The SSGCID consortium is directed by Dr. Peter Myler (principal investigator) and comprises many different scientists working at multiple centers towards determining the three-dimensional structures of proteins from biodefense organisms and emerging infectious diseases. Dylan K. Beard was part of a pilot Hampton University Chemistry Education and Mentorship Course-based undergraduate research (HU-ChEM CURES) funded by the NIGMS. | The structures are similar to those of BADH from ''Pseudomonas aeruginosa'' (''Pa''BADH). ''Pa''BADH is inhibited by the drug disulfiram which is an approved drug. Our preliminary analysis could facilitate drug repurposing studies for melioidosis. This project is an educational collaboration between the SSGCID and Hampton University. The SSGCID consortium is directed by Dr. Peter Myler (principal investigator) and comprises many different scientists working at multiple centers towards determining the three-dimensional structures of proteins from biodefense organisms and emerging infectious diseases. Dylan K. Beard was part of a pilot Hampton University Chemistry Education and Mentorship Course-based undergraduate research (HU-ChEM CURES) funded by the NIGMS. | ||
Revision as of 16:38, 19 December 2021
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This page complements a publication in scientific journals and is one of the Proteopedia's Interactive 3D Complement pages. For aditional details please see I3DC.
