2es6

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[[Image:2es6.gif|left|200px]]<br /><applet load="2es6" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2es6" />
 
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'''Structure of the SAM domain of Vts1p'''<br />
 
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==Overview==
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==Structure of the SAM domain of Vts1p==
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Although the abundant sterile alpha motif (SAM) domain was originally, classified as a protein-protein interaction domain, it has recently been, shown that certain SAM domains have the ability to bind RNA, defining a, new type of post-transcriptional gene regulator. To further understand the, function of SAM-RNA recognition, we determined the solution structures of, the SAM domain of the Saccharomyces cerevisiae Vts1p (Vts1p-SAM) and the, Smaug response element (SRE) stem-loop RNA as a complex and in isolation., The structures show that Vts1p-SAM recognizes predominantly the shape of, the SRE rather than its sequence, with the exception of a G located at the, tip of the pentaloop. Using microarray gene profiling, we identified, several genes in S. cerevisiae that seem to be regulated by Vts1p and, contain one or more copies of the SRE.
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<StructureSection load='2es6' size='340' side='right'caption='[[2es6]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2es6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ES6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ES6 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2es6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2es6 OCA], [https://pdbe.org/2es6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2es6 RCSB], [https://www.ebi.ac.uk/pdbsum/2es6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2es6 ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/es/2es6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2es6 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Although the abundant sterile alpha motif (SAM) domain was originally classified as a protein-protein interaction domain, it has recently been shown that certain SAM domains have the ability to bind RNA, defining a new type of post-transcriptional gene regulator. To further understand the function of SAM-RNA recognition, we determined the solution structures of the SAM domain of the Saccharomyces cerevisiae Vts1p (Vts1p-SAM) and the Smaug response element (SRE) stem-loop RNA as a complex and in isolation. The structures show that Vts1p-SAM recognizes predominantly the shape of the SRE rather than its sequence, with the exception of a G located at the tip of the pentaloop. Using microarray gene profiling, we identified several genes in S. cerevisiae that seem to be regulated by Vts1p and contain one or more copies of the SRE.
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==About this Structure==
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Shape-specific recognition in the structure of the Vts1p SAM domain with RNA.,Oberstrass FC, Lee A, Stefl R, Janis M, Chanfreau G, Allain FH Nat Struct Mol Biol. 2006 Feb;13(2):160-7. Epub 2006 Jan 22. PMID:16429156<ref>PMID:16429156</ref>
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2ES6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ES6 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Shape-specific recognition in the structure of the Vts1p SAM domain with RNA., Oberstrass FC, Lee A, Stefl R, Janis M, Chanfreau G, Allain FH, Nat Struct Mol Biol. 2006 Feb;13(2):160-7. Epub 2006 Jan 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16429156 16429156]
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</div>
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[[Category: Saccharomyces cerevisiae]]
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<div class="pdbe-citations 2es6" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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== References ==
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[[Category: Allain, F.H.T.]]
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<references/>
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[[Category: gene regulation]]
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__TOC__
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[[Category: protein structure]]
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</StructureSection>
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[[Category: sam domain]]
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[[Category: Atcc 18824]]
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[[Category: Large Structures]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:31:25 2008''
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[[Category: Allain, F H.T]]
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[[Category: Gene regulation]]
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[[Category: Protein structure]]
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[[Category: Sam domain]]

Current revision

Structure of the SAM domain of Vts1p

PDB ID 2es6

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