2exg
From Proteopedia
(Difference between revisions)
| (8 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:2exg.png|left|200px]] | ||
| - | + | ==Making Protein-Protein Interactions Drugable: Discovery of Low-Molecular-Weight Ligands for the AF6 PDZ Domain== | |
| - | + | <StructureSection load='2exg' size='340' side='right'caption='[[2exg]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2exg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EXG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=STF:(5R)-2-SULFANYL-5-[4-(TRIFLUOROMETHYL)BENZYL]-1,3-THIAZOL-4-ONE'>STF</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2exg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2exg OCA], [https://pdbe.org/2exg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2exg RCSB], [https://www.ebi.ac.uk/pdbsum/2exg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2exg ProSAT]</span></td></tr> |
| - | [[2exg]] is a 1 chain structure with sequence from [ | + | </table> |
| - | + | == Disease == | |
| - | == | + | [[https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein. |
| - | < | + | == Function == |
| - | [[Category: | + | [[https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. |
| - | [[Category: Boisguerin, P | + | == Evolutionary Conservation == |
| - | [[Category: Joshi, M | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[Category: Krause, G | + | Check<jmol> |
| - | [[Category: Oschkinat, H | + | <jmolCheckbox> |
| - | [[Category: Schade, M | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/2exg_consurf.spt"</scriptWhenChecked> |
| - | [[Category: Vargas, C | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2exg ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Boisguerin, P]] | ||
| + | [[Category: Joshi, M]] | ||
| + | [[Category: Krause, G]] | ||
| + | [[Category: Oschkinat, H]] | ||
| + | [[Category: Schade, M]] | ||
| + | [[Category: Vargas, C]] | ||
[[Category: Cell adhesion]] | [[Category: Cell adhesion]] | ||
[[Category: Inhibitors of protein-protein interaction]] | [[Category: Inhibitors of protein-protein interaction]] | ||
Current revision
Making Protein-Protein Interactions Drugable: Discovery of Low-Molecular-Weight Ligands for the AF6 PDZ Domain
| |||||||||||
