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2g6z
From Proteopedia
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==Crystal structure of human DUSP5== | ==Crystal structure of human DUSP5== | ||
| - | <StructureSection load='2g6z' size='340' side='right' caption='[[2g6z]], [[Resolution|resolution]] 2.70Å' scene=''> | + | <StructureSection load='2g6z' size='340' side='right'caption='[[2g6z]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2g6z]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2g6z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G6Z FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g6z OCA], [https://pdbe.org/2g6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g6z RCSB], [https://www.ebi.ac.uk/pdbsum/2g6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g6z ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/DUS5_HUMAN DUS5_HUMAN]] Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/2g6z_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/2g6z_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g6z ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[MAP kinase phosphatase|MAP kinase phosphatase]] | *[[MAP kinase phosphatase|MAP kinase phosphatase]] | ||
| - | *[[Tyrosine phosphatase|Tyrosine phosphatase]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
| + | [[Category: Large Structures]] | ||
[[Category: Kim, S J]] | [[Category: Kim, S J]] | ||
[[Category: Ryu, S E]] | [[Category: Ryu, S E]] | ||
[[Category: Alpha/beta]] | [[Category: Alpha/beta]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Current revision
Crystal structure of human DUSP5
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Categories: Human | Large Structures | Kim, S J | Ryu, S E | Alpha/beta | Hydrolase
