3bc3

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==Exploring inhibitor binding at the S subsites of cathepsin L==
==Exploring inhibitor binding at the S subsites of cathepsin L==
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<StructureSection load='3bc3' size='340' side='right' caption='[[3bc3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='3bc3' size='340' side='right'caption='[[3bc3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3bc3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BC3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BC3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3bc3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BC3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OPT:S-BENZYL-N-(BIPHENYL-4-YLACETYL)-L-CYSTEINYL-N~5~-(DIAMINOMETHYL)-D-ORNITHYL-N-(2-PHENYLETHYL)-L-TYROSINAMIDE'>OPT</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OPT:S-BENZYL-N-(BIPHENYL-4-YLACETYL)-L-CYSTEINYL-N~5~-(DIAMINOMETHYL)-D-ORNITHYL-N-(2-PHENYLETHYL)-L-TYROSINAMIDE'>OPT</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mhw|1mhw]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mhw|1mhw]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bc3 OCA], [http://pdbe.org/3bc3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bc3 RCSB], [http://www.ebi.ac.uk/pdbsum/3bc3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bc3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bc3 OCA], [https://pdbe.org/3bc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bc3 RCSB], [https://www.ebi.ac.uk/pdbsum/3bc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bc3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN]] Important for the overall degradation of proteins in lysosomes.
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[[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN]] Important for the overall degradation of proteins in lysosomes.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bc/3bc3_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bc/3bc3_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3bc3" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3bc3" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Cathepsin L]]
[[Category: Cathepsin L]]
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Bhat, S]]
[[Category: Bhat, S]]
[[Category: Chowdhury, S F]]
[[Category: Chowdhury, S F]]

Revision as of 11:30, 5 January 2022

Exploring inhibitor binding at the S subsites of cathepsin L

PDB ID 3bc3

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