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2qzf
From Proteopedia
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==SCR1 of DAF from 1ojv fitted into cryoEM density== | ==SCR1 of DAF from 1ojv fitted into cryoEM density== | ||
| - | < | + | <SX load='2qzf' size='340' side='right' viewer='molstar' caption='[[2qzf]], [[Resolution|resolution]] 14.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2qzf]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2qzf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QZF FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qzf OCA], [https://pdbe.org/2qzf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qzf RCSB], [https://www.ebi.ac.uk/pdbsum/2qzf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qzf ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/DAF_HUMAN DAF_HUMAN]] This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.<ref>PMID:7525274</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qz/2qzf_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qz/2qzf_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qzf ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2qzf" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[CD55|CD55]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
| - | </ | + | </SX> |
| - | [[Category: | + | [[Category: Human]] |
| - | [[Category: Bowman, V D | + | [[Category: Large Structures]] |
| - | [[Category: Chipman, P R | + | [[Category: Bowman, V D]] |
| - | [[Category: Hafenstein, S | + | [[Category: Chipman, P R]] |
| - | [[Category: Kelly, C M.Bator | + | [[Category: Hafenstein, S]] |
| - | [[Category: Lin, F | + | [[Category: Kelly, C M.Bator]] |
| - | [[Category: Medof, M E | + | [[Category: Lin, F]] |
| - | [[Category: Rossmann, M G | + | [[Category: Medof, M E]] |
| + | [[Category: Rossmann, M G]] | ||
[[Category: Blood group antigen]] | [[Category: Blood group antigen]] | ||
[[Category: Complement pathway]] | [[Category: Complement pathway]] | ||
Current revision
SCR1 of DAF from 1ojv fitted into cryoEM density
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Categories: Human | Large Structures | Bowman, V D | Chipman, P R | Hafenstein, S | Kelly, C M.Bator | Lin, F | Medof, M E | Rossmann, M G | Blood group antigen | Complement pathway | Glycoprotein | Gpi-anchor | Immune response | Immune system | Innate immunity | Lipoprotein | Membrane | Scr1 of daf from structure 1ojv fitted into cryoem density | Sushi
