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2qzf

From Proteopedia

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{{Seed}}
 
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[[Image:2qzf.png|left|200px]]
 
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<!--
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==SCR1 of DAF from 1ojv fitted into cryoEM density==
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The line below this paragraph, containing "STRUCTURE_2qzf", creates the "Structure Box" on the page.
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<SX load='2qzf' size='340' side='right' viewer='molstar' caption='[[2qzf]], [[Resolution|resolution]] 14.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2qzf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QZF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qzf OCA], [https://pdbe.org/2qzf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qzf RCSB], [https://www.ebi.ac.uk/pdbsum/2qzf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qzf ProSAT]</span></td></tr>
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-->
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</table>
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{{STRUCTURE_2qzf| PDB=2qzf | SCENE= }}
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== Function ==
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[[https://www.uniprot.org/uniprot/DAF_HUMAN DAF_HUMAN]] This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.<ref>PMID:7525274</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qz/2qzf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qzf ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Many entero-, parecho-, and rhinoviruses use immunoglobulin (Ig)-like receptors that bind into the viral canyon and are required to initiate viral uncoating during infection. However, some of these viruses use an alternative or additional receptor that binds outside the canyon. Both the coxsackievirus-adenovirus receptor (CAR), an Ig-like molecule that binds into the viral canyon, and decay-accelerating factor (DAF) have been identified as cellular receptors for coxsackievirus B3 (CVB3). A cryoelectron microscopy reconstruction of a variant of CVB3 complexed with DAF shows full occupancy of the DAF receptor in each of 60 binding sites. The DAF molecule bridges the canyon, blocking the CAR binding site and causing the two receptors to compete with one another. The binding site of DAF on CVB3 differs from the binding site of DAF on the surface of echoviruses, suggesting independent evolutionary processes.
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===SCR1 of DAF from 1ojv fitted into cryoEM density===
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Interaction of decay-accelerating factor with coxsackievirus B3.,Hafenstein S, Bowman VD, Chipman PR, Bator Kelly CM, Lin F, Medof ME, Rossmann MG J Virol. 2007 Dec;81(23):12927-35. Epub 2007 Sep 5. PMID:17804498<ref>PMID:17804498</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2qzf" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17804498}}, adds the Publication Abstract to the page
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*[[CD55|CD55]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17804498 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17804498}}
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__TOC__
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</SX>
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==About this Structure==
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[[Category: Human]]
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2QZF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QZF OCA].
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[[Category: Large Structures]]
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[[Category: Bowman, V D]]
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==Reference==
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[[Category: Chipman, P R]]
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Interaction of decay-accelerating factor with coxsackievirus B3., Hafenstein S, Bowman VD, Chipman PR, Bator Kelly CM, Lin F, Medof ME, Rossmann MG, J Virol. 2007 Dec;81(23):12927-35. Epub 2007 Sep 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17804498 17804498]
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[[Category: Hafenstein, S]]
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[[Category: Homo sapiens]]
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[[Category: Kelly, C M.Bator]]
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[[Category: Single protein]]
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[[Category: Lin, F]]
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[[Category: Bowman, V D.]]
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[[Category: Medof, M E]]
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[[Category: Chipman, P R.]]
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[[Category: Rossmann, M G]]
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[[Category: Hafenstein, S.]]
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[[Category: Kelly, C M.Bator.]]
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[[Category: Lin, F.]]
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[[Category: Medof, M E.]]
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[[Category: Rossmann, M G.]]
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[[Category: Alternative splicing]]
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[[Category: Blood group antigen]]
[[Category: Blood group antigen]]
[[Category: Complement pathway]]
[[Category: Complement pathway]]
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[[Category: Lipoprotein]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Membrane]]
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[[Category: Polymorphism]]
 
[[Category: Scr1 of daf from structure 1ojv fitted into cryoem density]]
[[Category: Scr1 of daf from structure 1ojv fitted into cryoem density]]
[[Category: Sushi]]
[[Category: Sushi]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:10:10 2008''
 

Current revision

SCR1 of DAF from 1ojv fitted into cryoEM density

2qzf, resolution 14.00Å

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